— To generate the mice, the researchers micro-injected ES cell clones carrying the targeted allele B2mtm1a(EUCOMM)Hmgu (B2mtm1a) into Albino B6 blastocysts.Chimeric mice were bred to Albino B6 to identify germline transmission by coat color. Mice containing the germline-transmitted B2mtm1a allele were…
— Disease indication – Tetracycline resistant infections
Drug format – Small molecule (anhydrotetracycline (aTC) or analogs)
Drug class – Combination therapy
Research stage and Preliminary data
Target – Tetracycline destructases (Tet(X), Tet(50), etc)
Background &ndas…
— Xcr1 IRES mCherry-hCre Mouse Strain
This genetically modified mouse strain expresses the fluorescent marker mCherry and a human codon optimzed Cre in the same transcript as the chemokine receptor XCR1. XCR1 is specifically expressed in cDC1s, allowing specific deletion of genes in and the fluoresce…
— Valosin Containing Protein (VCP) patient derived fibroblasts, reprogrammed into iPSC cells and corresponding gene corrected line. These cells can be used to model VCP associated muscle disease, ALS, and dementia.
— This is a brief (5 minutes exposition plus just under 5 minutes of questions) video that was designed for epidemiological research in tic disorders (including Tourette syndrome). The video shows lay people the broad definition of tics, so they can more accurately answer questions about whether they…
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