Xcr1 IRES mCherry-hCre Mouse Strain

by | Nov 13, 2019 | Durai, Vivek, Murphy, Kenneth, Murphy, Theresa

— Xcr1 IRES mCherry-hCre Mouse Strain

This genetically modified mouse strain expresses the fluorescent marker mCherry and a human codon optimzed Cre in the same transcript as the chemokine receptor XCR1. XCR1 is specifically expressed in cDC1s, allowing specific deletion of genes in and the fluoresce…

B6.129.Btla tm1kmm/J Mouse

by | Oct 22, 2019 | Murphy, Kenneth, Murphy, Theresa

— Notes: Btla-/- knockout mouse with a 129S/SvEv background. B6.129.Btla tm1kmm/J Mouse.

Knockout Mouse lacking Expression of the Batf3 Gene

by | Oct 22, 2019 | Diamond, Michael, Murphy, Kenneth, Murphy, Theresa, Schreiber, Robert, Unanue, Emil

— Notes: Batf3-/- knockout mouse with a 129SvEv background.

Modulation of Lymphocyte Activity

by | Mar 10, 2018 | Murphy, Kenneth, Murphy, Theresa, Watanabe, Norihiko, Yang, Jianfei

— Background: B and T lymphocyte attenuator (BTLA or CD272) is an inhibitory receptor expressed on T and B cells, dendritic cells and select myeloid cells. BTLA interacts with costimulatory molecule herpesvirus entry mediator (HVEM, Tnfrsf14, ATAR, HVEA, LIGHTR, or TR2). When bound to BTLA, HVEM atten…