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Dynamic seal valve to prevent aerosol infectionLowe, Halle ; Hartquist, Chase ; Zayed, Mohamed
T-019628
— Technology Description Researchers in Mohamed Zayed’s lab at Washington University have developed a dynamic seal valve that creates a seal around devices with varying cross sections. This valve could be deployed in masks to protect health care workers from aerosol infection while using airwa…
Passive and Compact Liquid Metal Heat SwitchWeisensee, Patricia
T-019180
— Technology Description Researchers in Patricia Weisensee’s lab at Washington University have developed a compact liquid metal heat switch with a passive mechanism to control the thermal management system of spacecraft. Unlike other switch mechanisms, the liquid metal version produces high co…
Trackable pedicle screwsMolina, Camilo ; Moran, Daniel ; Repka, Alicia ; Sandler, Jacob ; Hacker, Carl ; Lowe, Halle ; Genin, Guy ; Brunner, Peter ; Leuthardt, Eric
T-019941
— Technology Description Researchers at Washington University in St. Louis have developed a system that uses lenticular arrays to better track pedicle screw placement during spinal fusion surgery. By enabling an accurate assessment of the screws’ locations, this system allows for computer-auto…
Antisense oligo to enhance neuronal survival in Huntington’s DiseaseOh, Youngmi ; Yoo, Andrew
T-020121
— Technology Description Researchers in Andrew Yoo’s laboratory at Washington University have developed an antisense oligonucleotide targeting a miRNA (miR-29b-3p) as a treatment for Huntington’s disease (HD). Inhibiting miR-29b-3p promotes neuronal survival by rescuing neurons from deg…
Versatile airway management system to reduce exposure to aerosolized SARS-CoV-2 and other pathogensLee, Jin Vivian ; Iqbal, Zahid ; Zayed, Mohamed
T-019443
— Technology Description Researchers in Dr. Mohamed Zayed’s laboratory have developed a versatile, sealable valve system for airway management devices that can protect healthcare workers by reducing their risk of exposure to aerosolized SARS-CoV-2 and other pathogens during risky pulmonary pro…
Vascular graft to promote stem cell therapy for diabetes and other diseasesMillman, Jeffrey ; Zayed, Mohamed
T-016290
— Technology Description An interdisciplinary team at Washington University in St. Louis has developed a multi-layered arteriovenous graft device that enhances the survival and function of stem cell transplants to treat Type 1 diabetes or other diseases. Artificial organs derived from stem cells cou…
High-throughput blood biomarker test for peripheral atherosclerosisSemenkovich, Clay ; Zayed, Mohamed
T-017421
— Technology Description Researchers from Mohamed Zayed’s lab at Washington University have developed a blood biomarker test for atherosclerosis more accurate than LDL. Circulating levels of Fatty Acid Synthase (cFAS) in the serum correlate to a high degree to severity of peripheral atheroscle…
Vascular graft to promote stem cell therapy for diabetes and other diseasesMillman, Jeffrey ; Zayed, Mohamed
T-016290
— Technology Description An interdisciplinary team at Washington University in St. Louis has developed a multi-layered arteriovenous graft device that enhances the survival and function of stem cell transplants to treat Type 1 diabetes or other diseases. Artificial organs derived from stem cells cou…
Arteriovenous graft designed to prevent thrombosis and graft failureWilliams, Dillon ; Genin, Guy ; Zayed, Mohamed
T-018994
— Technology Description Prof. Mohamed Zayed and colleagues have developed an arteriovenous graft cuff with features designed to normalize the blood shear rate and decrease risk of thrombosis at the venous end anastomosis. This device could reduce the failure rate of these grafts, thereby improving …
Versatile airway management system to reduce exposure to aerosolized SARS-CoV-2 and other pathogensLee, Jin Vivian ; Iqbal, Zahid ; Zayed, Mohamed
T-019443
— Technology Description Researchers in Dr. Mohamed Zayed’s laboratory have developed a versatile, sealable valve system for airway management devices that can protect healthcare workers by reducing their risk of exposure to aerosolized SARS-CoV-2 and other pathogens during risky pulmonary pro…
High-throughput blood biomarker test for peripheral atherosclerosisSemenkovich, Clay ; Zayed, Mohamed
T-017421
— Technology Description Researchers from Mohamed Zayed’s lab at Washington University have developed a blood biomarker test for atherosclerosis more accurate than LDL. Circulating levels of Fatty Acid Synthase (cFAS) in the serum correlate to a high degree to severity of peripheral atheroscle…
Blockchain-based algorithms for secure, collaborative risk assessment and decision makingSalman, Tara ; Jain, Raj
T-018710
— Technology Description Researchers in Prof. Raj Jain’s laboratory have developed a new type of algorithm that extends the security of decentralized blockchains from consensus validation to efficient group decision making. This technology, called “probabilistic blockchains”, provi…
Deep Learning-Assisted Image Reconstruction for Tomographic ImagingMatthews, Thomas ; Kelly, Brendan ; Anastasio, Mark
T-017311
— Background Image reconstruction for any modern imaging technique is an optimization problem. Most image reconstructions methods are iterative in nature and produce sequential intermediate images that are compared to the raw acquisition data and subsequently updated to maximize the likelihood that t…
Combination therapy for malignant peripheral nerve sheath tumorsBorcherding, Dana ; Amin, Neha ; Hirbe, Angela
T-020000
— Technology Description Researchers in Angela Hirbe’s lab at Washington University have developed a method of treating malignant peripheral nerve sheath tumors (MPNSTs) with a combination of inhibitors. The most effective therapy is to combine an inhibitor of TYK2 with a MEK inhibitor. MPNST…
Range finder to improve X-ray image collectionClayton, William ; Don, Steven
T-014196
— Technology Description Researchers at Washington University in St. Louis have developed a device that automatically measures and displays body thickness to optimize X-ray image collection. This device will improve X-ray image quality and reduce the radiation exposure to patients. The device es…
Single cell massively parallel reporter assaysZhao, Siqi ; Cohen, Barak
T-019923
— Technology Description Researchers in Barak Cohen’s lab at Washington University have developed a method for single cell massively parallel reporter assay (scMPRA) to preserve cell type-specific information. This technology is scalable and sequencing platform agnostic. Massively parallel…
Single cell massively parallel reporter assaysZhao, Siqi ; Cohen, Barak
T-019923
— Technology Description Researchers in Barak Cohen’s lab at Washington University have developed a method for single cell massively parallel reporter assay (scMPRA) to preserve cell type-specific information. This technology is scalable and sequencing platform agnostic. Massively parallel…
Multi-Parametric Imaging of Tumor Heterogeneity Using Noninvasive, Non-radiative Water DiffusionWang, Qing ; Guzman, Gloria ; Benzinger, Tammie ; Wang, Yong
T-016652
— Background Currently, biopsies are the only definitive method to diagnose a brain tumor. While PET-CT is used for initial imaging and monitoring of the tumor, after completion of treatments, a 6-8-week delay is usually implemented to avoid false-positive results. Yet, the delay could also result in…
Tumor Detection Using Digitally Enhanced and Stimulated Thermal ImagingShmuylovich, Leonid ; O'Brien, Christine ; Mondal, Suman ; Meng, Hongyu ; Achilefu, Samuel
T-018541
— Background Temperature differences between tumor and healthy tissue due to increased blood flow and metabolic activity are exploited for thermal imaging (TI) as an adjunct imaging modality for cancer diagnosis. Despite many technological advances and recent improvements, TI has a limited tumor dept…
Technique to reduce juxta-anastomotic stenosis development in AV fistulaeShenoy, Surendra
T-010339
— Technology Description Researchers at Washington University in St. Louis have developed a technique for arteriovenous fistula creation that reduces the incidence of juxta-anastomotic stenosis, which often leads to graft failure. The procedure involves clamping closed one end of the graft and attac…
