Advanced Search
Select the Categories and/or Inventors to begin filtering. To narrow search results, use the search bar for additional keywords.
Search returned 630 results
Anti-FCRL5 Chimeric Antigen Receptor (CAR) Targeting Multiple MyelomaGhobadi, Armin ; Ritchey, Julie ; DiPersio, John ; O'Neal, Julie
T-020082
— Published Date: 5/13/2025 Value Proposition: An innovative therapy leveraging unique chimeric antigen receptors (CAR) to specifically target Fc receptor-like 5 (FCRL5), enabling the precise elimination of FCRL5-expressing cells to treat multiple myeloma and other cancers. Technology Description …
Antisense Oligo to Enhance Neuronal Survival in Huntington’s DiseaseOh, Youngmi ; Yoo, Andrew
T-020121
— Published Date: 5/14/2025 Value Proposition: Novel antisense oligonucleotide (ASO) directly targeting a microRNA-mediated mechanism responsible for autophagy reduction and neurodegeneration in Huntington’s disease (HD) improving patient outcomes in pre-HD subjects. Technology Description R…
Functional Biomarkers of Platinum Chemotherapy and PARP Inhibitor ResponseZhao, Peinan ; Verma, Priyanka ; Lomonosova, Elena ; Mullen, Mary
T-020659
— Published Date: 5/14/2025 Value Proposition: Robust and reliable biomarker to accurately predict patient response to PARP inhibitors and platinum chemotherapy for high grade serous ovarian cancer. Technology Description Researchers at Washington University in St. Louis have developed an automat…
CAR Macrophages for Targeted Degradation of Pathogenic SubstancesLee, Jin-Moo ; Diwan, Abhinav ; DeSelm, Carl
T-020543
— Published Date: 5/14/2025 Value proposition: Self-sustaining chimeric macrophages as a novel approach to target amyloid plaques resulting in improved efficacy and survival in patients. Technology Description Researchers from Washington University in St. Louis have engineered macrophages to expre…
Effector CAR T-Cells for Treatment of Alzheimer’s DiseaseBoskovic, Pavle ; Kipnis, Jonathan
T-020995
— Published Date: 5/14/2025 Value proposition: Using CAR T-cells to treat Alzheimer’s disease and other neurodegenerative diseases through Ab-specific activation. Technology Description While CD4+ (helper or effector) T-cells play complex roles in the pathophysiology of Alzheimer’s …
Antisense Oligonucleotides (ASOs) to Treat Neurodegeneration in ALS and FTDPirzada, Mujeeb ; Djuranovic, Sergej
T-021032
— Published Date: 5/14/2025 Value proposition: Novel ASOs that increase key protein production to limit neurodegeneration caused by ALS and frontotemporal dementia (FTD). Technology Description TDP-43 pathology is present in ~97% of ALS, ~50% of FTD, and frequently observed in other neurodegenerat…
Novel Neurosteroids for Treating Pain DisordersCovey, Douglas
T-021245
— Published Date: 5/15/2025 Value proposition: Novel analgesic compounds that block CaV3.2 currents in nociceptive dorsal root ganglion neurons in order preemptively treat pain in subjects, unlike other products that are continuously administered post onset of pain. Technology Description Resear…
Gene-Specific Therapy Treatment for Predicting Limb-Girdle Muscular DystrophyWeihl, Conrad ; Li, Chengcheng ; Haller, Gabriel
T-020804
— Published Date: 5/14/2025 Value Proposition: Method that uses gene-therapy to detect limb-girdle muscular dystrophy (LGMD) type 4R/2E. Technology Description Researchers at Washington University in St. Louis have developed a method of predicting limb-girdle muscular dystrophy (LGMD) type 4R/2…
Antagonizing the Endothelin B Receptor to Improve Aging-Dependent Neuronal Regenerative DeclineFeng, Rui ; Cavalli, Valeria
T-020705
— Published Date: 12/21/24 Value proposition: A cost-effective, drug-based therapy targeting the endothelin B receptor (ETBR) to promote peripheral nerve regeneration, offering improved recovery and compatibility with existing treatments. Technology Description Researchers at Washington University…
Plasma-based cfRNA Biomarkers for Parkinson’s DiseaseBeric, Aleksandra ; Ibanez, Laura
T-021115
— Published Date: 5/13/2025 Value Proposition: Plasma cell-free transcripts that can be used as biomarkers to aid in the diagnosis and monitoring of Parkinsons Disease. Technology Description Researchers at Washington University in St. Louis have developed a panel of cell free RNA (cfRNA) biomark…
Targeting Neuronal Hyperexcitability to Treat Central and Peripheral Nervous System NF1 TumorsAnastasaki, Corina ; Gutmann, David
T-020010
— Published Date: 5/13/2025 Value Proposition: A novel approach to repurposing FDA-approved anti-epileptic drugs to treat brain and nerve tumors associated with neurofibromatosis type I, offering a faster, cost-effective pathway to address an urgent unmet medical need. Technology Description Neuro…
Engineered transient autoimmune (ETA) T cell therapy for CNS injuryKipnis, Jonathan
T-019788
— Published Date: 5/13/2025 Value Proposition: Promotion of recovery and reduction of neuronal damage following nerve injury, first T cell approach to neurological disorders. Technology Description Traumatic injuries to the spinal cord or the brain currently have limited treatment options, particu…
“Guardian” Brain Peptides as Autoimmune TherapeuticKim, Min Woo "Mitch" ; Kipnis, Jonathan
T-020431
— Published Date: 5/13/2025 Value proposition: New therapeutic modality that uses CNS self-peptides to treat autoimmune diseases, reducing neuroinflammation damage in an organ-specific manner. Technology Description Autoimmune diseases continue to debilitate countless individuals, increasing healt…
Manipulating T Cell Regulatory Genes to Improve CAR T Cell TherapySingh, Nathan
T-020330
— Published Date: 12/24/2024 Value proposition: An advanced CAR-T cell therapy engineered to reduce T cell exhaustion, enhancing durability and effectiveness in cancer treatment by overcoming one of the leading causes of long-term treatment failure. Technology Description Researchers at Washington…
Improved Alzheimer’s Disease Detection Using Cell-Free RNA AnalysisCruchaga, Carlos ; Cisterna Garcia, Alejandro ; Ibanez, Laura
T-020079
— Published Date: 5/10/2025 Value Proposition: Method that uses plasma cfRNAs to differentiate Alzheimer’s disease from healthy controls. Technology Description Researchers at Washington University in St. Louis have developed a series of models using blood-based biomarkers to detect Alzheimer …
Blood-based Biomarkers for IL-23 Inhibitor Response in IBDDeepak, Parakkal ; Cao, Siyan
T-020960
— Published Date: 5/10/2025 Value Proposition: Diagnostic method that uses the patient’s PBMCs acquired before or immediately after the onset of IL-23 therapy to determine the presence of signatures indicative of long-term IL-23 response. Technology Description Researchers at Washington Univ…
GDF-15: A Diagnostic Biomarker for GlaucomaYoshino, Jun ; Apte, Rajendra
T-016002
— Published Date: 4/29/2025 Value Proposition: Novel biomarker that can be used as a diagnostic to identify glaucoma severity or progression in patients. Technology Description Researchers at Washington University in St. Louis have identified a novel biomarker, GDF15, for glaucoma that can detect …
WHICH-A.R.T: Method for Accurately Detecting Male InfertilityZhao, Peinan ; Ferreira, Juan ; Santi Grau Perez, Celia
T-020924
— Published date: 3/14/2025 WHICH-A.R.T: Method for Accurately Detecting Male Infertility Value Proposition: Fertility treatment designed to quickly and accurately detect the fertilization capacity of sperm. Technology Description Researchers at Washington University in St. Louis have developed…
Gene-Edited iNKT Cell Expressing Chimeric Antigen Receptor for the Treatment of CancerDiPersio, John ; Cooper, Matthew
T-018642
— Value Proposition: Engineered iNKT cells with potential as a “universal” source of immune effector cells to treat cancer. Technology Description Researchers at Washington University in St. Louis have developed a new composition of matter that uses gene-edited invariant natural kill…
AntiFake: Computer Method Designed to Prevent Unauthorized Speech SynthesisYu, Zhiyuan ; Zhang, Ning
T-020985
— Published Date: 2/14/2025 Value Proposition: Speech synthesizer that uses adversarial audio to prevent the creation of deepfakes. Technology Description Researchers at Washington University in St. Louis have developed a computer implemented method for generating audio content that introduces per…
