— Published Date: 1/4/2025
Value Proposition: New composition of matter that combines tetracycline class compounds with destructase inhibitors to overcome resistance to tetracycline antibiotics.
Technology Description
Researchers at Washington University in St. Louis have developed an enzymatic…
— Published Date: 1/4/2025
Value Proposition: New composition of matter that combines tetracycline class compounds with destructase inhibitors to overcome resistance to tetracycline antibiotics.
Technology Description
Researchers at Washington University in St. Louis have developed an enzymatic…
— Chemists from Washington University have discovered and characterized an enzyme pathway that could be harnessed as an efficient platform to produce peptide beta-lactone libraries for drug discovery. Beta-lactones are a family of molecules with a structure similar to penicillin and therefore could po…
— Clifednamide A and C are congeners of long known ikarugamycin. Ikarugamycin has anti-inflammatory, anti-ciliate, plant modulatory and other desirable bioactivities. These clifednamide compounds may also have therapeutic, industrial or agricultural value.
Publication: Qi, Y., Ding, E., & Blodget…
— Disease indication – Tetracycline resistant infections
Drug format – Small molecule (anhydrotetracycline (aTC) or analogs)
Drug class – Combination therapy
Research stage and Preliminary data
Target – Tetracycline destructases (Tet(X), Tet(50), etc)
Background &ndas…
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Creating...
