by | Sep 8, 2020 | Reck, Margaret, Schaffer, Jason, Wencewicz, Timothy
— Chemists from Washington University have discovered and characterized an enzyme pathway that could be harnessed as an efficient platform to produce peptide beta-lactone libraries for drug discovery. Beta-lactones are a family of molecules with a structure similar to penicillin and therefore could po…
by | Aug 24, 2020 | Qi, Yunci, Van Dyke-Blodgett, Joshua, Wencewicz, Timothy, Yang, Jinping
— Clifednamide A and C are congeners of long known ikarugamycin. Ikarugamycin has anti-inflammatory, anti-ciliate, plant modulatory and other desirable bioactivities. These clifednamide compounds may also have therapeutic, industrial or agricultural value.
Publication: Qi, Y., Ding, E., & Blodget…
by | Nov 18, 2019 | Dantas, Gautam, Forsberg, Kevin, Gasparrini, Andrew, Park, Jooyoung, Tolia, Niraj, Vogel, Joseph, Wencewicz, Timothy
— Disease indication – Tetracycline resistant infections
Drug format – Small molecule (anhydrotetracycline (aTC) or analogs)
Drug class – Combination therapy
Research stage and Preliminary data
Target – Tetracycline destructases (Tet(X), Tet(50), etc)
Background &ndas…