Small molecule inhibitors to prevent tetracycline resistance

by | Nov 18, 2019 | Dantas, Gautam, Forsberg, Kevin, Gasparrini, Andrew, Park, Jooyoung, Tolia, Niraj, Vogel, Joseph, Wencewicz, Timothy

— Disease indication – Tetracycline resistant infections

Drug format – Small molecule (anhydrotetracycline (aTC) or analogs)

Drug class – Combination therapy

Research stage and Preliminary data

Target – Tetracycline destructases (Tet(X), Tet(50), etc)

Background &ndas…