Mouse and Human Anti-MR1 Hybridoma

by | Dec 5, 2019 | Cella, Marina, Colonna, Marco, Fremont, Daved, Gilfillan, Susan, Hansen, Ted, Myers, Nancy

— Target: Major Histocompatibility Complex, Class 1-Related Protein

Notes: Clone available is 26.5

Hybridoma clone 26.5 secreting mAb 26.5 to human and mouse MR1, an MHC-like molecule that restricts the activation of anti-microbial MIAT cells.

Publication: Evidence for MR1 Antigen Presentation to Mucosal-associated Invariant T Cells

Potent, locally-acting chemokine binding proteins to protect organ transplants and treat ischemic or inflammatory diseases

by | Oct 22, 2019 | Fremont, Daved, Lu, Yun Hsuan, Lubman, Olga

— Researchers in Prof. Daved Fremont’s laboratory have identified two potent, soluble proteins that could prevent damage to transplanted organs and potentially treat other autoimmune and inflammatory diseases by evading the immune response instigated by chemokines.

In organ transplants, chemoki…

Targeting B Cells for Antibody-Mediated Graft Rejection

by | Oct 22, 2019 | Edelson, Brian, Fremont, Daved, Liu, Chang, Nelson, Christopher, Wang, Xiaoli

— Disease Indications

Drug type: Biologic – engineered protein

Drug class: First in class

Technology:

A recombinant fusion protein that depletes B cells in the recipient that are specific to the donor HLA. The fusion protein offers a targeted therapy for antibody-mediated rejection in the …