by | Dec 12, 2019 | Hansen, Ted, Lybarger, Lonnie, Wang, Xiaoli
— Target: Amino acids 11-34 of mouse tapasin.
Application(s): Western Blotting
Armenian hamster mAb (5D3) was produced to peptide EDAGGGGLSKKPATLLLRH GPRGP, representing residues 11–34 on mouse Tapasin (TPN) (44). TPN mAb was found to be specific for mouse TPN, as determined in a Western blot analysis of cell lysates of .221 (human TPN-positive) cells, .220 (human TPN-n…
by | Dec 12, 2019 | Hansen, Ted, Wang, Xiaoli
— mAb 4E3 was derived by immunization of β2m-deficient BALB/c mice with a keyhole limpet hemocyanin-conjugated peptide corresponding to mMR1 residues 130–153 (L A M D Y V A H I T K Q A W E A N L H E L Q Y Q). Hybridomas were produced by standard methods and screened by anti-peptide ELISA.
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by | Oct 22, 2019 | Edelson, Brian, Fremont, Daved, Liu, Chang, Nelson, Christopher, Wang, Xiaoli
— Disease Indications
Drug type: Biologic – engineered protein
Drug class: First in class
Technology:
A recombinant fusion protein that depletes B cells in the recipient that are specific to the donor HLA. The fusion protein offers a targeted therapy for antibody-mediated rejection in the …
