TREM2 blockade as an adjuvant for checkpoint inhibitors

— Disease indication – In combination with anti-PD-1 therapy for cancer. Anti-PD-1 therapy is currently approved for:

Drug format – Monoclonal antibody

Drug class – First-in-class

Target – TREM2

Research stage and preliminary data – The inventors performed initia…

IL-34-deficient reporter mice (IL34 LacZ/LacZ)

— Mouse strain deficient in IL-34 production with defective Langerhans cells and microglia. These mice can be used to assess the role of the cytokine IL-34 in the development and maintenance of peripheral macrophage populations.

Publication: Wang, Y., Szretter, K. J., Vermi, W., Gilfillan, S., Rossin…

CD226 (DNAM1) knockout mice

— This is a mouse knockout strain for CD26, also known as DNAM-1 (DNAX accessory molecule 1). DNAM-1 is an adhesion molecule belonging to the immunoglobulin superfamily. This mouse model was used to study the role of DNAM-1 on CD8 T cell and NK cell function in vitro and in vivo.

Publication: Gilfill…

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