Alphavirus-Resistant Fish

Background: Aquaculture is the most resource-efficient method to produce protein, improve nutrition, and food security and is vital for supporting seafood production. The Food and Agriculture Organization of the United Nations estimates over 50% of all global seafood for human consumption is produce…

Mayaro virus monoclonal antibodies and hybridomas

— Mayaro virus (MAYV) is an emerging mosquito-transmitted alphavirus. This is a panel of 18 neutralizing mAbs agains MAYV, 11 of which have activity that inhibited infection with EC50 values <10ng/ml. Earnest, J. T., Basore, K., Roy, V., Bailey, A. L., Wang, D., Alter, G., ... & Diamond, M. S.…

Irg1 conditional knockout mouse

— Irg1−/− mice were generated after receiving embryonic stem cells (ESCs) from the Knockout Mouse Project Repository containing an insertion cassette between exons 3 and 4. This cassette prevents transcription of downstream exons 4 and 5 and production of mature protein. Irg1−/&minu…

LDLRAD3 KO mice

— Venezuelan equine encephalitis virus (VEEV) is an emerging infectious disease in South America transmitted by mosquitos. VEEV usually resides in forest and swamp areas where human populations are limited, however, VEEV has the potential to cause epidemics in humans and equines. LDLRAD3 has been foun…

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