— VLDLR-based Decoy Receptors to Prevent Alphavirus Infections
Technology Description
Researchers at Washington University in St. Louis have developed very low-density lipoprotein receptor (VLDLR) soluble decoy receptors with potent inhibitory activity in vitro and in vivo. Eastern equine encephali…
— Disease indication – SARS-CoV-2 infection (COVID-19)
Drug format – Chimeric monoclonal antibody
Drug class – Best-in-class
Research stage and Preliminary data – The inventors have developed and characterized this antibody, creating a chimeric version with a human IgG backbone. T…
— Disease indication – Venezuelan equine encephalitis virus (VEEV) infection, either naturally-arising and as a result of bioterrorism
Drug format – Biologic (soluble receptor fusion protein)
Drug class – First-in-class
Mode of action – This soluble fusion protein contains domain …
— A number of bacterial and mammalian expression vectors for production of SARS-CoV proteins that can be used for immunization, B-cell sorting, and human serum evaluation are available.
Expression constructs produce: spike, ACE2, CD147, Surface display, SARS-1 and SARS-2 ORF7a, ORF8, and nucleocapsid…
— Species: Mouse
Target: SARS-CoV-2 spike protein
Applications:
Description: Four murine monoclonal antibodies that recognize SARS-CoV-2 spike protein. Data below includes avaiable antibodies (mCoV.1.1C02; mCoV.1.2C08; mCoV.1.2D09; mCoV.1.2F05).
Related Web Links: Ellebedy Profile; Ellebedy Lab
…
— Species: Mouse
Target: SARS-CoV-2 spike protein
Applications:
Data: See table below for library of antibodies, inventor can recommend specific clones based on intended application.
Related Web Links: Diamond Profile
Available Antibodies
Ab:
Well #
Final Boost
flow cytometer…
| Name | # Summaries | Author |
|---|---|---|
| 15 | ||
| 13 | ||
| 15 | ||
| 26 | ||
| 14 | ||
| 14 |
Creating...
