Mouse embryonic fibroblasts from IRF 3/5/7 knock out animals

by | Jan 31, 2020 | Diamond, Michael

— Mouse fibroblasts are isolated from Irf3-/-xlrf5-/-xlrf7-/-TKO mice. Researchers generated the mouse strains from an inbred C57BL/6 background.

Associated Publication: IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling

Monoclonal Antibodies Against Zika Virus and Purified Zika E Protein

by | Dec 18, 2019 | Diamond, Michael, Fernandez, Estefania, Fremont, Daved, Nelson, Christopher, Platt, Derek, Zhao, Haiyan

— To generate a panel of antibodies against ZIKV, we serially infected Irf3/ mice 30 days apart with ZIKV MR-766 (Uganda, 1947) and ZIKV H/PF/2013 (French Polynesia, 2013). Irf3/ mice were used instead of wild-type (WT) mice, because ZIKV strains are deficient in evading type I interferon-mediated imm…

Antibodies to Western Equine Encephalitis Virus (WEEV)

by | Nov 13, 2019 | Austin, Stephen, Diamond, Michael, VanBlargan, Laura

— Antibodies against Western Equine Encephalitis Virus (WEEV)

Inventors demonstrated the antibodies reactivity with WEEV-infected cells or with WEEV proteins. These antibodies can be used for diagnostic and potentially therapeutic purposes.

Target and method to treat alphavirus infections

by | Oct 22, 2019 | Basore, Katherine, Diamond, Michael, Fremont, Daved, Kim, Arthur, Nelson, Christopher, Thackray, Larissa, Zhang, Rong

— Technology Description

Researchers at Washington University in St. Louis have identified a target for therapeutic development and created methods to potentially treat arthritogenic alphavirus infection. Arthritogenic alphaviruses, including chikungunya (CHIKV), Ross River, Mayaro and O’nyong…