Hamster Hybridoma producing Monoclonal Antibody against Murine IFNAR-1

— Target: Type-1 interferon receptor subunit, a key signaling receptor in the interferon pathway.

Notes: Clones MAR1-5A3, MAR1 -1H5, MAR1-3A7, MAR1-4D12, MAR1-4F12

Monclonal antibodies specific for MuIFNAR1 were isolated from hybridomas developed following immunization of IFNAR1 gene targeted mice with purified plasmid encoding the the extracellular domain of murine IFNAR1 expressed in pRK5 using a method of hydrodynamic immunization.


d42m1 & F279 tumor cell lines

— D42m1 is a methycholanthrene (MCA) induced sarcoma cell line generated in 129S6 strain RAG2 gene targeted mice. These cells are highly immunogenic and are rejected when transplanted into syngeneic naive wild type mice.

F244 is an MCA induced sarcoma cell line generated in wild type 129S6 mice. Thes…

Murine neoantigen containing plasmids

— Two plasmids each containing a single murine mutant tumor neoantigen:

a) retroviral MSCV-IRES encoding full length mutant lamanin alpha 4 (mLama4)

b) retroviral MSCV plasmid encoding full length mutant integrin beta 1 (mItgb1)

Hamster Hybridoma producing Monoclonal Antibody against Mouse CXCR3

— Target: C-X-C chemokine family member (CXCR3). Expressed on NK cells, activated T lymphocytes, select

endothelial and epithelial cells.

Hamsters were immunized with a multiple antigens peptide-8 (MAPS-8) encompassing amino acids 1 to 37 of mouse CXCR3 in complete Freund’s adjuvant, and boosted with peptide in incomplete Freund’s adjuvant. Hamsters showing ELISA seropositivity for CXCR3 peptide were boosted and hybridomas gen…
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