Lyz2Cre;Talin-1fl/fl mice

by | Nov 20, 2019 | Randolph, Gwendalyn

— Lyz2Cre;Talin-1fl/fl mouse strain

Inventors crossed Talin-1fl/fl mice (received from Oklahoma Medical Research Foundation) with Lyz2Cre mice (available at the Jackson Laboratory) to generate Lyz2Cre;Talin-1fl/fl mice.

— This is a trangenic mouse with the floxed Stat1 gene. This mouse can be breed with whole body or tissue specific Cre lines to knockout out STAT1 – which is a transcription factor that is essential for the interferon signaling pathway.

Publication: Respiratory Enterovirus (Like Parainfluenza Virus)…

Expression plasmid to examine Kelch domain of Keap 1

by | Nov 13, 2019 | Amarasinghe, Gaya

— This expression plasmid can be used to identify inhibitors for Keap1 – a pathway that is invoIved in oxidative stress response and implicated in Marburg virus infection.

Publication: Dimerization controls Marburg virus VP24-dependent modulation of host antioxidative stress responses

Plasmids for luciferase expression in Cryptosporidium

by | Nov 13, 2019 | Funkhouser-Jones, Lisa, Sibley, Laurence David

— Plasmids for luciferase expression in Cryptosporidium

The plasmids listed below are for targeting insertion into the TK and UPRT loci in Cryptosporidium parvum. To generate the plasmids, the inventors modified a previously described nanoluciferase (Nluc) reporter fused to neomycin resistance (NeoR)…

Bhlhe40 flox/flox mice

by | Nov 13, 2019 | Edelson, Brian

— The Bhlhe40 flox/flox mice on the C57BL/6 background originated as a KO-first promoter-driven mouse line from the Knockout Mouse Project and were purchased from the Jackson Laboratory. These initial mice contained a Bhlhe40 allele with a splice acceptor-LacZ reporter and a Neo cassette flanked by tw…