— Description: 2ftgh-ISRE-CBG99 cell line- a report line for interferon stimulation. To create these cells the inventors generated a report plasmid of interferon-stimulated response element (5xISRE)-driven luciferase, and co-transfected this vector together with pPUR plasmid into the human 2ftgh fibr…
— This is a trangenic mouse with the floxed Stat1 gene. This mouse can be breed with whole body or tissue specific Cre lines to knockout out STAT1 – which is a transcription factor that is essential for the interferon signaling pathway.
Publication: Respiratory Enterovirus (Like Parainfluenza Virus)…
— Disease indications:
Drug format: small molecule
Drug class: first in class
Research stage and Preliminary data:
Preclinical development of the lead compound for respiratory disease includes in vitro and in vivo efficacy, selectivity and initial toxicity testing. Preclinical development of the…
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Creating...
