by | Jan 21, 2020 | Liu, Hui, Rosenberg, Adam, Tu, Zhude "Will", Yue, Xuyi
— Technology Description
Researchers at Washington University in St. Louis have developed sphingosine 1-phosphate receptor 1 (S1P1)-specific PET tracers. Sphingosine 1-phosphate receptors are G-protein coupled receptors, with five subtypes denoted S1P1-5, that have key functions in immune, inflammat…
by | Dec 12, 2019 | Hansen, Ted, Lybarger, Lonnie, Wang, Xiaoli
— Target: Amino acids 11-34 of mouse tapasin.
Application(s): Western Blotting
Armenian hamster mAb (5D3) was produced to peptide EDAGGGGLSKKPATLLLRH GPRGP, representing residues 11–34 on mouse Tapasin (TPN) (44). TPN mAb was found to be specific for mouse TPN, as determined in a Western blot analysis of cell lysates of .221 (human TPN-positive) cells, .220 (human TPN-n…
by | Dec 11, 2019 | Bertram, Paula, Hourcade, Dennis
— Target: Full length mouse properdin
Application(s): Western blot and immunofluorescence
Two functional properties of one of the two hamster antibodies have been examined, the H4 subclone of the 3D12 clone. In experiments the H4 antibody was used to identify mouse properdin present in histological sections, to block mouse properdin function in vitro, and to ameliorate complement alterna…
by | Nov 6, 2019 | Allen, Paul
— Target: Full length mouse Vb 8.3 TCR but not 8.1 or 8.2. Vb 8.3.
Application: Flow cytometry
This antibody was made by immunizing Armenian hamsters. It was used to study the mechanisms that act to keep only one functional TCR beta-chain per cell and the effect of selecting ligand density on positive selection and endogenous receptor usage in mice.
Publication: TCR transgenic mice in which …
by | Oct 22, 2019 | Klechevsky, Eynav
— Background
Dendritic cells (DCs) are antigen-presenting cells that are essential to the adaptability of the immune system. Several subsets of DCs have been identified in tissues that interface with the environment (e.g. skin, mucosal lining). While the role of specific DC subsets are unknown, DCs p…
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