— Description: Dnmt3b transgenic mouse contains a full-length Flag-tagged murine Dnmt3b cDNA which is under the control of a rtTA promoter. The Dnmt3b transgenic mouse will provide both cell specific and temporal regulation for Dnmt3b over-expression upon recombination with addition of doxycycline (D…
— A team of researchers at Washington University in St. Louis has identified an epigenetic pathway and two therapeutic targets that could be used to prevent cartilage loss and counteract the mechanism underlying osteoarthritis. The inventors have seen promising results in a mouse model of arthritis us…
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