by | Jul 22, 2020 | Guilak, Farshid, Pferdehirt, Lara
— Using CRISPR-based gene editing, decorin was inserted downstream of Smad7 to create autoregulated stem cells that can produce decorin. As Smad7 is activated during TGF-beta signaling, the stems cells produce decorin in response to TGF-beta. Decorin is a key modulator of extracellular matrix assembly…
by | Apr 16, 2020 | Guilak, Farshid
— Technology Description
Researchers at Washington University in St. Louis have developed a method to create designer stem cells which provide a safer, more effective cell therapy approach to treating disease. Cell-based regenerative therapies could potentially be used to treat many diseases and res…
