Sigma-1 targeted PET tracers

— Technology Description

Researchers at Washington University in St. Louis and their colleagues have developed positron emission tomography (PET) tracers with high affinity for sigma-1 receptors. Sigma receptors have two subtypes, sigma-1 and sigma-2. Sigma-1 has high expression in the limbic and mo…

S1P1-targeted PET tracers

— Technology Description

Researchers at Washington University in St. Louis have developed sphingosine 1-phosphate receptor 1 (S1P1)-specific PET tracers. Sphingosine 1-phosphate receptors are G-protein coupled receptors, with five subtypes denoted S1P1-5, that have key functions in immune, inflammat…

S1PR2-targeted PET tracers

— Technology Description

Researchers at Washington University in St. Louis and colleagues have developed S1PR2-targeted PET tracers. Sphingosine-1-phosphate (S1P) is an important bioactive lipid that regulates critical biological functions by acting through five specific G protein-coupled S1P recept…

S1P1-targeted PET tracers

— Technology Description

Researchers at Washington University in St. Louis have developed sphingosine 1-phosphate receptor 1 (S1P1)-specific PET tracers. Sphingosine 1-phosphate receptors are G-protein coupled receptors, with five subtypes denoted S1P1-5, that have key functions in immune, inflammat…

F-18 radiotracer for alpha-synuclein

— These materials are an alpha-synuclein binding compound (standard), and the precursor for PET radiolabeling the compound. Precursor's code name: TZ61-23; chemical name: 2-((6-methoxypyridin-3-yl)amino)quinolin-6-ol. Standard's code name: TZ61-44; chemical name: 6-(2-fluoroexthoxy)-N-(6-metho…

TZ4877 and 18F-radiolabeling precursor TZ50153

— TZ4877 is a ligand for the sphingosine-1-phosphate (S1P) receptor 1 in the CNS, developed and radiolabeled with fluorine-18. TZ4877 is the standard (non-radioactive compound) which is used for HPLC analysis of the S1P1 PET tracer, [18F]TZ4877. TZ50153 is the radiolabeling precursor of the PET tracer…

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