Modulation of Lymphocyte Activity

by | Mar 10, 2018 | Murphy, Kenneth, Murphy, Theresa, Watanabe, Norihiko, Yang, Jianfei

— Background: B and T lymphocyte attenuator (BTLA or CD272) is an inhibitory receptor expressed on T and B cells, dendritic cells and select myeloid cells. BTLA interacts with costimulatory molecule herpesvirus entry mediator (HVEM, Tnfrsf14, ATAR, HVEA, LIGHTR, or TR2). When bound to BTLA, HVEM atten…