by | Jan 19, 2024 | Lomonosova, Elena, Mullen, Mary, Verma, Priyanka, Zhao, Peinan
— T-020659 — Functional Biomarkers of Platinum Chemotherapy and PARP Inhibitor Response
Technology Description
Most patients diagnosed with high-grade serous ovarian cancer (HGSOC) undergo first-line platinum therapy and PARP inhibitor maintenance therapy. However, the degree to which HGSOC p…
by | Jul 10, 2023 | Hatoum, Alexander
— Technology Description
Researchers at Washington University in St. Louis, led by Dr. Alexander Hatoum, have developed a computational model for improving the diagnosis and treatment of drug addiction. Using genome-wide association study (GWAS) of over 1 million subjects, Dr. Hatoum’s group d…
by | Jul 21, 2022 | Cohen, Barak, Zhao, Siqi
— Technology Description
Researchers in Barak Cohen’s lab at Washington University have developed a method for single cell massively parallel reporter assay (scMPRA) to preserve cell type-specific information. This technology is scalable and sequencing platform agnostic.
Massively parallel…
by | Apr 27, 2022 | Chang, Ju Fang, Singh, Nathan
— Technology Description
Researchers in Nathan Singh’s lab at Washington University have developed a construct for cell therapy that combines facets of existing CAR-T therapy and the endogenous T cell receptor (TCR) to better regulate adoptive cell activation. Unlike the traditional TCR, this …
by | Jan 13, 2022 | DeSelm, Carl
— Technology Description
Researchers at Washington University in St. Louis have developed a genetic method to produce chimeric antigen receptor dendritic cells (CAR-DCs) for the treatment of solid tumors. The team generated a CAR that drives differentiation of cDC1s and mediates tumor-specific uptak…