Engineering of T Cell Regulatory Genes to Improve CAR T Cell Therapy

by | Dec 23, 2024 | Singh, Nathan

— Published Date: 12/24/2024

Value proposition: Improved method using edited CAR-Ts to reduce T cell exhaustion and enhance cancer treatments.

Technology Description

High tumor burden and repeated antigen stimulation are often associated with the lack of durable remission from CAR-T therapy. Res…

Optimized MHC-independent T cell receptors as a CAR-T alternative

by | Apr 27, 2022 | Chang, Ju Fang, Singh, Nathan

— Technology Description

Researchers in Nathan Singh’s lab at Washington University have developed a construct for cell therapy that combines facets of existing CAR-T therapy and the endogenous T cell receptor (TCR) to better regulate adoptive cell activation. Unlike the traditional TCR, this …

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Engineering of T Cell Regulatory Genes to Improve CAR T Cell Therapy

Optimized MHC-independent T cell receptors as a CAR-T alternative

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​​Engineering of T Cell Regulatory Genes to Improve CAR T Cell Therapy​

Optimized MHC-independent T cell receptors as a CAR-T alternative

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Engineering of T Cell Regulatory Genes to Improve CAR T Cell Therapy