Manipulating T Cell Regulatory Genes to Improve CAR T Cell Therapy

by | May 12, 2025 | Singh, Nathan

— Published Date: 12/24/2024

Value proposition: An advanced CAR-T cell therapy engineered to reduce T cell exhaustion, enhancing durability and effectiveness in cancer treatment by overcoming one of the leading causes of long-term treatment failure.

Technology Description

Researchers at Washington…

Optimized MHC-independent T cell receptors as a CAR-T alternative

by | Apr 27, 2022 | Chang, Ju Fang, Singh, Nathan

— Technology Description

Researchers in Nathan Singh’s lab at Washington University have developed a construct for cell therapy that combines facets of existing CAR-T therapy and the endogenous T cell receptor (TCR) to better regulate adoptive cell activation. Unlike the traditional TCR, this …

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Manipulating T Cell Regulatory Genes to Improve CAR T Cell Therapy

Optimized MHC-independent T cell receptors as a CAR-T alternative

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Manipulating T Cell Regulatory Genes to Improve CAR T Cell Therapy​

Optimized MHC-independent T cell receptors as a CAR-T alternative

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Manipulating T Cell Regulatory Genes to Improve CAR T Cell Therapy