Hamster Hybridoma producing Monoclonal Antibody against Murine IFNAR-1

— Target: Type-1 interferon receptor subunit, a key signaling receptor in the interferon pathway.

Notes: Clones MAR1-5A3, MAR1 -1H5, MAR1-3A7, MAR1-4D12, MAR1-4F12

Monclonal antibodies specific for MuIFNAR1 were isolated from hybridomas developed following immunization of IFNAR1 gene targeted mice with purified plasmid encoding the the extracellular domain of murine IFNAR1 expressed in pRK5 using a method of hydrodynamic immunization.

Publication:

d42m1 & F279 tumor cell lines

— D42m1 is a methycholanthrene (MCA) induced sarcoma cell line generated in 129S6 strain RAG2 gene targeted mice. These cells are highly immunogenic and are rejected when transplanted into syngeneic naive wild type mice.

F244 is an MCA induced sarcoma cell line generated in wild type 129S6 mice. Thes…

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