by | Sep 17, 2021 | Crowley, Jan, Henderson, Jeffrey P., Robinson, John
— Technology Description
Researchers in Prof. Jeffrey Henderson’s laboratory have developed a method of analyzing metabolic biomarkers from fecal samples to more accurately identify C. difficile infection (CDI) and distinguish between symptomatic and asymptomatic colonization. CDI is currently …
by | Sep 9, 2021 | Choi, Kyunghee, Kabir, Ashraf Ul, Krchma, Karen
— Technology Description
Researchers in Kyunghee Choi’s lab at Washington University in St. Louis have identified a novel target, Myct1, that modulates tumor angiogenesis and anti-tumor immune response. Myct1 inhibition with siRNA blocks angiogenesis and promotes infiltration of cytotoxic T ly…
by | Sep 2, 2021 | Schreiber, Robert, Sheehan, Kathleen
— Target: Type-1 interferon receptor subunit, a key signaling receptor in the interferon pathway.
Notes: Clones MAR1-5A3, MAR1 -1H5, MAR1-3A7, MAR1-4D12, MAR1-4F12
Monclonal antibodies specific for MuIFNAR1 were isolated from hybridomas developed following immunization of IFNAR1 gene targeted mice with purified plasmid encoding the the extracellular domain of murine IFNAR1 expressed in pRK5 using a method of hydrodynamic immunization.
Publication:
by | Sep 2, 2021 | Schreiber, Robert
— D42m1 is a methycholanthrene (MCA) induced sarcoma cell line generated in 129S6 strain RAG2 gene targeted mice. These cells are highly immunogenic and are rejected when transplanted into syngeneic naive wild type mice.
F244 is an MCA induced sarcoma cell line generated in wild type 129S6 mice. Thes…
by | Nov 18, 2020 | Henderson, Jeffrey P., Marks, Laura, Robinson, John
— Technology Description
A team of researchers has discovered a urinary metabolite pattern occurring early in COVID-19 disease progression that can predict which patients infected with SARS-CoV-2 are at high risk for respiratory failure or death. This metabolite signature could potentially provide a…