by | Mar 10, 2018 | Goldberg, Daniel, Sigala, Paul
— Background: Malaria, mainly caused by Plasmodium falciparum, results in over 200 million clinical cases a year and approximately 430,000 deaths a year. Tropical and sub-tropical countries have a high incidence of malaria cases because Anopheles mosquitoes thrive in warm temperatures and are able to …
by | Mar 10, 2018 | Anastasaki, Corina, Gutmann, David
— Background: Neurofibromatosis type 1 (NF1) is a common neurological condition affecting roughly 1 in every 2,500 individuals. NF1 is associated with a host of clinical presentations, including malignant tumors and cognitive defects ranging from attention deficits, mental retardation, and autism. The…
by | Mar 10, 2018 | Albring, Jorn, Murphy, Kenneth, Sandau, Michelle
— Background: Allogeneic hematopoietic stem-cell transplantation (aHSCT) from a healthy donor can cure a variety of blood cell disorders including leukemia, multiple myeloma, and some types of lymphoma. This has resulted in an increasing number of transplants, surpassing 8,000 a year in the US alone. …
by | Mar 10, 2018 | Ding, Li, Koboldt, Daniel, Larson, David, McLellan, Michael, Wylie, Todd
— arScan is a Java-based, platform-independent, software tool that can detect variants in next-generation sequencing (NGS) data. It employs a robust statistical approach to call variants and is able to handle germline variants, multi-sample variants, somatic mutations and somatic copy number alterati…
by | Mar 10, 2018 | Henderson, Jeffrey P., Hung, Chia, Parker, Kaveri
— Urinary tract infection (UTI) caused by uropathogenic Escherichia coli (UPEC) is one of the most common infectious diseases in women. The morbidity and economic impact are enormous, with over $2.5 billion spent annually on treatment. The high rates of recurrence, and the large numbers of women that …