Mice with Mutant Gtf2i and Gtf2ird1 Alleles
— Dr. Dougherty developed a collection of mouse lines with deletions of Gft2i and Gtfird1 in various combinations. The genes are related to Williams Beuren locus.
Publications:
Transgenic zebrafish line expressing gCAMP in the pancreatic beta cell
— Stable zebrafish line that shows calcium signaling within the pancreatic beta cells. The line was generated using the calcium sensing fluorophore gCAMP and integrated using the TOL2 transcription factor.
Publication: Beta-cell excitability and excitability-driven diabetes in adult Zebrafish islets
Prognostic for Lymphoproliferative Disorders
— Technology Description
Researchers at Washington University in St. Louis have developed an improved method to monitor the progression of lymphoproliferative disorders (LPDs) and guide treatment decisions. LPDs, including leukemia and lymphoma, are characterized by the abnormal proliferation of blo…
Stem cells that produce decorin
— Using CRISPR-based gene editing, decorin was inserted downstream of Smad7 to create autoregulated stem cells that can produce decorin. As Smad7 is activated during TGF-beta signaling, the stems cells produce decorin in response to TGF-beta. Decorin is a key modulator of extracellular matrix assembly…
Elastin conditional knockout mouse
— Mouse with floxed elastin gene to conditionally inactivate elastin gene expression.
Publication: Heterogeneous Cellular Contributions to Elastic Laminae Formation in Arterial Wall Development
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