Stem cells that produce decorin

by | Jul 22, 2020 | Guilak, Farshid, Pferdehirt, Lara

— Using CRISPR-based gene editing, decorin was inserted downstream of Smad7 to create autoregulated stem cells that can produce decorin. As Smad7 is activated during TGF-beta signaling, the stems cells produce decorin in response to TGF-beta. Decorin is a key modulator of extracellular matrix assembly…