by | Jan 25, 2021 | Basore, Katherine, Diamond, Michael, Fremont, Daved, Kafai, Natasha, Kim, Arthur, Ma, Hongming, Thackray, Larissa
— Disease indication – Venezuelan equine encephalitis virus (VEEV) infection, either naturally-arising and as a result of bioterrorism
Drug format – Biologic (soluble receptor fusion protein)
Drug class – First-in-class
Mode of action – This soluble fusion protein contains domain …
by | Dec 11, 2020 | Luhmann, Scott
— Technology Description:
Researchers at Washington University in St. Louis have identified blood-based cytokine signatures that could be used to specifically detect, distinguish and monitor septic arthritis, synovitis and osteomyelitis. This assay could enable timely, accurate treatment to avoid joi…
by | Nov 16, 2020 | Buchser, William, Lalli, Matthew, Milbrandt, Jeffrey, Mitra, Robi
— Technology Description
A team of Washington University researchers has developed a low-cost molecular diagnostics kit and reader that could provide rapid, widespread screening and surveillance for SARS-CoV-2 and other infections. This technology utilizes a reverse-transcription loop-mediated isot…
by | Oct 2, 2020 | Storch, Gregory, Yu, Jinsheng
— Technology Description
Researchers in Prof. Gregory Storch’s laboratory have developed a molecular assay that utilizes the patient/host gene expression pattern to rapidly identify acute group A streptococcus (GAS) infection in patients with pharyngitis (sore throat) to help guide appropriate…
by | Sep 8, 2020 | Reck, Margaret, Schaffer, Jason, Wencewicz, Timothy
— Chemists from Washington University have discovered and characterized an enzyme pathway that could be harnessed as an efficient platform to produce peptide beta-lactone libraries for drug discovery. Beta-lactones are a family of molecules with a structure similar to penicillin and therefore could po…