by | Jan 25, 2022 | Bloom, Adam, DiAntonio, Aaron, Mao, Xianrong, Milbrandt, Jeffrey
— Technology Description
Researchers at Washington University, led by Jeffrey Milbrandt, have developed a companion diagnostic for SARM1 inhibitors that detects pathogenic variants of the SARM1 gene. Patients with one of several identified variants of SARM1 would respond well to SARM1 inhibitor thera…
by | Nov 16, 2020 | Buchser, William, Lalli, Matthew, Milbrandt, Jeffrey, Mitra, Robi
— Technology Description
A team of Washington University researchers has developed a low-cost molecular diagnostics kit and reader that could provide rapid, widespread screening and surveillance for SARS-CoV-2 and other infections. This technology utilizes a reverse-transcription loop-mediated isot…
by | Nov 16, 2020 | Buchser, William, Lalli, Matthew, Milbrandt, Jeffrey, Mitra, Robi
— Technology Description
A team of Washington University researchers has developed a low-cost molecular diagnostics kit and reader that could provide rapid, widespread screening and surveillance for SARS-CoV-2 and other infections. This technology utilizes a reverse-transcription loop-mediated isot…
by | Apr 8, 2020 | DiAntonio, Aaron, Milbrandt, Jeffrey
— Crispr developed SARM1 Knockout Rat
by | Apr 7, 2020 | Jain, Sanjay, Milbrandt, Jeffrey
— Using the Cre-deletor strain Hoxb7-Cre, Washington University researchers developed transgenic mice with loxP sites flanking the gene for the glial cell line-derived neurotrophic factor (GDNF) family receptor α1 (GFRα1), which is involved in kidney tissue development. These mice were the…
by | Mar 10, 2018 | DiAntonio, Aaron, Milbrandt, Jeffrey, Miller, Bradley, Press, Craig
— Background: Axonal degeneration is a feature commonly associated with many neuropathological conditions including response to injury, exposure to neurotoxins, hereditary neuropathies, glaucoma, and neurodegenerative diseases. The degenerative process is active when neuronal insults trigger a self-de…