— Murine tumor cell lines
Murine syngeneic MCA induced tumor lines have been developed and characterized by the Schreiber Lab and provide critical models to study drugs or pathways that impact tumor growth or rejection. In particular they are used to study mechanism of action of immune checkpoint blo…
— This technology contains a panel of human or mouse specific monomers for staining T cells to enumerate antigen specific cells. The proteins have been produced in E coli after the generation of plasmids encoding each monomer. The proteins are folded in association with unique peptides and purified by…
— Target: Mouse/rat interleukin-1 beta and mouse interleukin-1 alpha. Located on macrophages, dendritic cells, T and B cells.
Notes: Clone name is B-122 and Alf-161
The role of murine IL-1 beta in vitro and in vivo has not been defined. We describe here the production of neutralizing and immunoprecipitating mAb and polyclonal antibodies specific for murine IL-1 beta and their application to a characterization of the…
— Notes: STAT1-/- knockout mouse with a 129S6 background
— Notes: Batf3-/- knockout mouse with a 129SvEv background.
— Target: Inflammatory chemokine CXCL9, monokine induced by IFN-gamma. Secreted mainly by macrophages.
Notes: Clone MIG-2F5-5. Use in ELISA, neutralizing and binding assays.
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