by | Aug 24, 2020 | Colonna, Marco, Gilfillan, Susan, Wang, Yaming
— Mouse line knockouts of IL-34. IL-34 is a growth factor for macrophages, microglia, and Langerhans cells, among others.
Publication: IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia
by | Aug 24, 2020 | Colonna, Marco, Gilfillan, Susan, Yoshita, Satoru
— The Colonna lab generated two IL-33 knockout mouse lines – a total and a conditional knockout models. IL-33 is a crucial mediator of inflammation.
Publication: IL-33/regulatory T cell axis triggers the development of a tumor-promoting immune environment in chronic inflammation
by | Aug 24, 2020 | Colonna, Marco, Gilfillan, Susan, Joshita, Satoru
— Reporter mouse line that allows for identification of cells productive IL-33 through mCherry expression. IL-33 is a molecule involved in immune system responses to helminths, allergies, and asthma.
Publications:
by | Aug 13, 2020 | Cella, Marina, Colonna, Marco
— Mouse monoclonal antibodies recognizing human IL-26
by | Jan 31, 2020 | Caparon, Michael, Cervantes-Barragan, Luisa, Colonna, Marco, Di Luccia, Blanda
— Bacteria modified from the parental strain Lactobacillus reuteri 100-23 that doesn’t express the enzyme aryl aminotransferase. Culture supernatants from this bacterial strain failed to stimulate AhR reporter cells.
Publication: Lactobacillus reuteri induces gut intraepithelial CD4+CD8α&al…
by | Dec 5, 2019 | Cella, Marina, Colonna, Marco, Fremont, Daved, Gilfillan, Susan, Hansen, Ted, Myers, Nancy
— Target: Major Histocompatibility Complex, Class 1-Related Protein
Notes: Clone available is 26.5
Hybridoma clone 26.5 secreting mAb 26.5 to human and mouse MR1, an MHC-like molecule that restricts the activation of anti-microbial MIAT cells.
Publication: Evidence for MR1 Antigen Presentation to Mucosal-associated Invariant T Cells