Mouse strain deficient in IL-34 production with defective Langerhans cells and microglia. These mice can be used to assess the role of the cytokine IL-34 in the development and maintenance of peripheral macrophage populations.

Publication: Wang, Y., Szretter, K. J., Vermi, W., Gilfillan, S., Rossini, C., Cella, M., … & Colonna, M. (2012). IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia. Nature immunology, 13(8), 753-760.