— This mouse strain has a genetic alteration in STAT3 and can be used to understand the role of STAT3 in human disease.
Publication: Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations
— CHO Gadd7 knockdown cell lines
Inventors generated two stable Chinese Hamster Ovary (CHO) cell lines with knockdown of gadd7 by transfecting cells with a custom siRNA plasmid targeting hamster gadd7 (KD1 and KD2) and a control CHO cell line by transfecting cells with a custom scrambled siRNA plasmi…
— Crry-knockout mouse strain (Crry -/-)
Publication: A Critical Role for Murine Complement Regulator Crry in Fe…
— Target: Mouse/rat interleukin-1 beta and mouse interleukin-1 alpha. Located on macrophages, dendritic cells, T and B cells.
Notes: Clone name is B-122 and Alf-161
The role of murine IL-1 beta in vitro and in vivo has not been defined. We describe here the production of neutralizing and immunoprecipitating mAb and polyclonal antibodies specific for murine IL-1 beta and their application to a characterization of the…
— Mouse strain deficient in IL-1 beta
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