Floxed ChAT mouse strain

— This mouse strain has loxP sites flanking exons 3 and 4 of the ChAT gene. There is a Neo gene in the intron between exons 4 and 5. Mating these mice to A-Cre mice generates a null allele in subsequent generations, in which no ChAT protein or activity is detectable. The mice are maintained in the C57…

Transgenic mouse lines with markers of muscle development

— Myl-CFP Mice

The coding sequence for the enhanced CFP was inserted downstream of ~5kb of putative regulatory sequences from the mouse myosin Type I heavy chain gene. Transgenic mice were generated by pronuclear injection using standard methods.

JAX Stock No. 06922

MyIIA-RFP Mice

A ~100kb genomic…

Hamster Hybridoma producing Monoclonal Antibody against Mouse CXCR3

— Target: C-X-C chemokine family member (CXCR3). Expressed on NK cells, activated T lymphocytes, select

endothelial and epithelial cells.

Hamsters were immunized with a multiple antigens peptide-8 (MAPS-8) encompassing amino acids 1 to 37 of mouse CXCR3 in complete Freund’s adjuvant, and boosted with peptide in incomplete Freund’s adjuvant. Hamsters showing ELISA seropositivity for CXCR3 peptide were boosted and hybridomas gen…

Murine Tumor Cell Lines

— Murine tumor cell lines

Murine syngeneic MCA induced tumor lines have been developed and characterized by the Schreiber Lab and provide critical models to study drugs or pathways that impact tumor growth or rejection. In particular they are used to study mechanism of action of immune checkpoint blo…

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