Mouse with Arg1809Cys Nf1 gene mutation
— This mouse strain was designed to harbor a specific NF1 patient germline NF1 gene mutation.
Nf1 Optic Glioma Stem Cells
— Using a series of Nf1 genetically-engineered mouse strains, researchers isolated low-grade glioma stem cells (CD133+ cells) for in vitro and in vivo brain tumor studies. These lines are authenticated optic glioma stem cells, with the ability to self-renew at limiting dilutions; express stem cell mar…
Tumor treatment for patients with neurofibromatosis type 1 (NF1)
— Technology Description
Scientists at the Washington University Neurofibromatosis Center have developed a patented, first-in-class method for treating neurofibromatosis type 1 (NF1) with small molecule inhibitors of targets in the mTOR (mammalian target of rapamycin) signaling pathway. NF1 is a rel…
Neurofibromin/dopamine signaling as a biomarker for cognitive and behavioral problems in children with neurofibromatosis type 1 (NF1)
— Background: Neurofibromatosis type 1 (NF1) is a common neurological condition affecting roughly 1 in every 2,500 individuals. NF1 is associated with a host of clinical presentations, including malignant tumors and cognitive defects ranging from attention deficits, mental retardation, and autism. The…
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