— Background:
Viral vectors have been used for in vivo delivery of CRISPR/Cas9. However, it’s applications have been limited by the native tropism of the viral vector. To better utilize in vivo editing, methods must be developed to accomplish efficient, selective and coordinated delivery of CRI…
— Technology Description
An interdisciplinary team at Washington University has developed low-cost, easy-to-use, nanoparticles that can preserve antibodies, proteins and other biological molecules without refrigeration. This technology employs metal organic frameworks (MOF) that can be used in two w…
— Mouse line knockouts of IL-34. IL-34 is a growth factor for macrophages, microglia, and Langerhans cells, among others.
Publication: IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia
— The Colonna lab generated two IL-33 knockout mouse lines – a total and a conditional knockout models. IL-33 is a crucial mediator of inflammation.
Publication: IL-33/regulatory T cell axis triggers the development of a tumor-promoting immune environment in chronic inflammation
— Reporter mouse line that allows for identification of cells productive IL-33 through mCherry expression. IL-33 is a molecule involved in immune system responses to helminths, allergies, and asthma.
Publications:
| Name | # Summaries | Author |
|---|---|---|
| 15 | ||
| 13 | ||
| 15 | ||
| 26 | ||
| 14 | ||
| 14 |
Creating...
