CEPT1 floxed mice

— C57BL/6 ES cells were targeted with a vector (European Conditional Mouse Mutagenesis Program) carrying loxP sites flanking exon 3 of mouse Cept1. A karyotypically normal clone (of 10 correctly targeted) was injected into B6(Cg)-Tyrc-2J/J blastocysts and chimeric mice were bred with B6(Cg)-Tyrc2J/J f…

IL-34-deficient reporter mice (IL34 LacZ/LacZ)

— Mouse strain deficient in IL-34 production with defective Langerhans cells and microglia. These mice can be used to assess the role of the cytokine IL-34 in the development and maintenance of peripheral macrophage populations.

Publication: Wang, Y., Szretter, K. J., Vermi, W., Gilfillan, S., Rossin…

Generating pancreatic beta cells from pluripotent stem cells for diabetes cell therapy or drug development

— Technology Description:

Researchers in Prof. Jeffrey Millman’s laboratory have developed multiple techniques for enhancing the differentiation, maturation and function of glucose-responsive, insulin-producing SC-beta cells (pancreatic beta cells made from human pluripotent stem cells). Downst…

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