Transcription factor EB (TFEB) materials
— Materials that have been used to study transcription factor EB (TFEB), a lysosomal biogenesis factor:
Mouse monoclonal antibodies against SARS-CoV-2 nucleocapsid protein
— These are six monoclonal antibodies specific to SARS-CoV-2 Nucleocapsid protein that could potentially be used for COVID-19 diagnostics.
Inflammatory bowel disease biomarkers and therapeutic target
— Plasminogen activator inhibitor-1 (PAI-1) has been identified as a specific biomarker that is significantly elevated in patients with inflammatory bowel disease (IBD) and is correlated with disease severity. It could be used to both diagnose the disease (including ulcerative colitis and colonic Croh…
Mayaro virus monoclonal antibodies and hybridomas
— Mayaro virus (MAYV) is an emerging mosquito-transmitted alphavirus. This is a panel of 18 neutralizing mAbs agains MAYV, 11 of which have activity that inhibited infection with EC50 values <10ng/ml. Earnest, J. T., Basore, K., Roy, V., Bailey, A. L., Wang, D., Alter, G., ... & Diamond, M. S.…
In vivo editing via targeted adenoviral vectors
— Background:
Viral vectors have been used for in vivo delivery of CRISPR/Cas9. However, it’s applications have been limited by the native tropism of the viral vector. To better utilize in vivo editing, methods must be developed to accomplish efficient, selective and coordinated delivery of CRI…
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