by | Jun 17, 2022 | Bowman, Brittany, Dolle, Roland "Ron", Lapak, Kyle, Major, Michael "Ben", Medcalf, Matthew
— Disease indication – Diseases related to oxidative stress, including cancer, autoimmune disease, and Toxoplasma infection
Drug format – Small molecule
Drug class – Best-in-class
Research stage and preliminary data – The researchers have synthesized a series of pyrimethamin…
by | Apr 20, 2022 | Jain, Umang, Stappenbeck, Thaddeus
— Technology Description:
Researchers at Washington University in St. Louis have identified a new avenue for treatment of non-healing ulcers in patients with Crohn’s disease by targeting Debaryomyces hansenii. While the cause of Crohn’s disease is unknown, the fungus D. hansenii colonize…
by | Apr 13, 2022 | Colonna, Marco, Secca da Silva, Cristiane
— Disease indication – Autoimmune diseases (plaque psoriasis, psoriatic arthritis, Crohn’s disease)
Drug format – Monoclonal antibody
Drug class – First-in-class
Research stage and preliminary data – Researchers have stimulated human ILC3s with IL-23 in vitro, with and…
by | Mar 10, 2022 | Kremer, Jeff, Lange, Sara, Van Tine, Brian
— Background: Synovial sarcoma is a rare soft tissue sarcoma that most commonly affects young adults. Like many other cancers, there are currently no targeted chemotherapies for synovial sarcoma. Current treatment often consists of a combination of surgery, radiation therapy, and chemotherapy. The met…
by | Sep 29, 2021 | Ellebedy, Ali
— Disease indication – SARS-CoV-2 infection (COVID-19)
Drug format
Drug class – Best-in-class
Research stage and Preliminary data – The inventors have developed and characterized these antibodies, creating a chimeric version with a human IgG backbone for SARS2-38. The antibodies have …