ME1 Deficiency Primes for Ferroptosis

— Background: Synovial sarcoma is a rare soft tissue sarcoma that most commonly affects young adults. Like many other cancers, there are currently no targeted chemotherapies for synovial sarcoma. Current treatment often consists of a combination of surgery, radiation therapy, and chemotherapy. The met…

ME1 Deficiency Primes for Ferroptosis

— Background: Synovial sarcoma is a rare soft tissue sarcoma that most commonly affects young adults. Like many other cancers, there are currently no targeted chemotherapies for synovial sarcoma. Current treatment often consists of a combination of surgery, radiation therapy, and chemotherapy. The met…

TREM2 blockade as an adjuvant for checkpoint inhibitors

— Disease indication – In combination with anti-PD-1 therapy for cancer. Anti-PD-1 therapy is currently approved for:

Drug format – Monoclonal antibody

Drug class – First-in-class

Target – TREM2

Research stage and preliminary data – The inventors performed initia…

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