— VP35 is involved in multiple functions crticial to viral replication in filoviruses such as Ebola and Marburg virus. Viruses with VP35 mutations are attenuated in in vivo models. 5.4 million compounds were screened for their ability to bind to VP35 at the key protein-to-protein interface. The screen…
— pSL2231 is a derivative of pBR322 that can be used to delete the nblA gene in Synechococcus UTEX 2973.
Publication: Synechococcus elongatus UTEX 2973, a fast growing cyanobacterial chassis for biosynthesis using light and CO2
— Two shuttle vectors, pCA-UC118 and pCB-SC101, capable of replication in both Synechocystis 6803 and E. coli. Expression of reporter proteins were significantly enhanced in cells containing these new plasmids, thus providing superior gene expression platforms in this cyanobacterium.
Publication: …
— Plasmid for CRISPR interference in Synechococcus sp. UTEX 2973:
pSL3287 (Addgene), included in publication: Tunable repression of key photosynthetic processes using Cas12a CRISPR interference in the fast-growing cyanobacterium Synechoccoccus sp. UTEX 2973
Plasmids for high level of sucrose produ…
— Background: Recombinant vesicular stomatitis virus (VSV) has successfully been used to create a vaccine for Ebola virus that is currently on the market. Previously, Professor Sean Whelan and colleagues have exploited the VSV platform to create similar vectors for both SARS and MERS.
Technology: The…
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