by | Jul 26, 2022 | Amin, Neha, Borcherding, Dana, Hirbe, Angela
— Technology Description
Researchers in Angela Hirbe’s lab at Washington University have developed a method of treating malignant peripheral nerve sheath tumors (MPNSTs) with a combination of inhibitors. The most effective therapy is to combine an inhibitor of TYK2 with a MEK inhibitor.
MPNST…
by | Jul 18, 2022 | Benzinger, Tammie, Guzman, Gloria, Wang, Qing, Wang, Yong
— Background
Currently, biopsies are the only definitive method to diagnose a brain tumor. While PET-CT is used for initial imaging and monitoring of the tumor, after completion of treatments, a 6-8-week delay is usually implemented to avoid false-positive results. Yet, the delay could also result in…
by | Jul 5, 2022 | Achilefu, Samuel, Meng, Hongyu, Mondal, Suman, O'Brien, Christine, Shmuylovich, Leonid
— Background
Temperature differences between tumor and healthy tissue due to increased blood flow and metabolic activity are exploited for thermal imaging (TI) as an adjunct imaging modality for cancer diagnosis. Despite many technological advances and recent improvements, TI has a limited tumor dept…
by | Jun 17, 2022 | Bowman, Brittany, Dolle, Roland "Ron", Lapak, Kyle, Major, Michael "Ben", Medcalf, Matthew
— Disease indication – Diseases related to oxidative stress, including cancer, autoimmune disease, and Toxoplasma infection
Drug format – Small molecule
Drug class – Best-in-class
Research stage and preliminary data – The researchers have synthesized a series of pyrimethamin…
by | Apr 27, 2022 | Chang, Ju Fang, Singh, Nathan
— Technology Description
Researchers in Nathan Singh’s lab at Washington University have developed a construct for cell therapy that combines facets of existing CAR-T therapy and the endogenous T cell receptor (TCR) to better regulate adoptive cell activation. Unlike the traditional TCR, this …