PI3K inhibitors to treat Cytokine Release Syndrome

by | Jan 15, 2021 | Amatya, Parmeshwar, Carter, Alun, Cooper, Matthew, DiPersio, John

— Technology Description

A team of researchers, led by John DiPersio and Matthew Cooper at Washington University in St. Louis, have identified a small molecule kinase inhibitor capable of mitigating cytokine release syndrome following CAR-T cell therapy. PI3K inhibitors can suppress production of IL-…