by | Mar 10, 2018 | Dodd, Sherry, Garbutt, Jane, Highstein, Gabrielle, Rook, Shannon, Strunk, Robert
— Background: Many children with asthma live with frequent symptoms and activity limitations, and visits for urgent care are common. Pediatricians do not typically meet with families regularly in order to monitor asthma, identify possible problems with the management of the child’s asthma, or pr…
by | Mar 10, 2018 | Achilefu, Samuel, Berezin, Mikhail, Zhang, Zongren
— Background: Near Infrared (NIR) fluorescence can be highly useful in biological systems as it is highly sensitive and allows for detection and imaging of physiological and molecular processes in cells and living organisms. However, radiometric imaging is difficult in the NIR region of the light spec…
by | Mar 10, 2018 | Becker, Matthew, Fang, Huafeng, Pan, Dipanjan, Rossin, Raffaella, Sun, Xiankai, Taylor, John-Stephen, Turner, Jeffrey, Welch, Michael, Wooley, Karen
— This invention features cell permeable nano conjugates of shell-cross-linked knedel (SCK) and peptide nucleic acids (PNA) with mRNA targeting sequences for early diagnosis and therapy of cancers.
by | Mar 10, 2018 | Hallahan, Dennis
— Technology: GRP78 is a chaperone that is part of a complex that controls the maturation of glycoproteins in the ER and senses cellular stress in normal cells. However, following radiation treatment, GRP78 is also expressed on the surface of cancer cells and has anti-apoptotic and pro-angiogenesis ac…
by | Mar 10, 2018 | Rossin, Raffaella, Welch, Michael, Woodard, Pamela
— Background
Atherosclerosis is a disease process in which lipid deposition causes the formation of plaques that lead to thickening of the artery walls. The cause of a majority of fatal acute myocardial infarction and sudden coronary death is due to the rupture of soft or unstable plaques; however, t…