by | Jul 5, 2022 | Achilefu, Samuel, Meng, Hongyu, Mondal, Suman, O'Brien, Christine, Shmuylovich, Leonid
— Background
Temperature differences between tumor and healthy tissue due to increased blood flow and metabolic activity are exploited for thermal imaging (TI) as an adjunct imaging modality for cancer diagnosis. Despite many technological advances and recent improvements, TI has a limited tumor dept…
by | Feb 14, 2020 | Achilefu, Samuel
— Description: Calcium Carbonate nanoparticles for normalizing tumor microenvironment
Publication: Som A, Raliya R, Tian L, Akers W, Ippolito JE, Singamaneni S, Biswas P, Achilefu S. Monodispersed calcium carbonate nanoparticles modulate local pH and inhibit tumor growth in vivo. Nanoscale. 2016 Jul …
by | Nov 7, 2019 | Achilefu, Samuel, Sharmah Gautam, Krishna
— Fluorescent tagged octapeptide for cancer detection
by | Jul 31, 2018 | Achilefu, Samuel, Ye, Yunpeng
— Technology Description: Macrocyclic Molecular Beacons Useful for Medical applications :US 20070098638 (published US application) : The sensitivity and specificity of the optical modality can be enhanced by the use of highly absorbing compounds as contrast agents. Novel macrocyclic cyanine and indocy…
by | Mar 10, 2018 | Achilefu, Samuel, Kotagiri, Nalinikanth
— Background: Around 1 million patients receive radiation therapy every year with an estimated cost of $2,000 per treatment. The market demands technologies that can provide efficacious therapeutics and diagnostic imaging while minimizing harmful side effects. Photodynamic therapy can simultaneously s…
by | Mar 10, 2018 | Achilefu, Samuel, Black, Kvar
— This invention is the formulation of a SPECT nanoparticle probe for the detection of MMP activity. The surface of a 10 nm-sized gold nanoparticle is functionalized through a thiol anchor with a peptide that is cleaved in the presence of MMP9. The surface is also functionalized with methoxy polyethyl…