by | Mar 10, 2018 | Ding, Li, Koboldt, Daniel, Larson, David, McLellan, Michael, Wylie, Todd
— arScan is a Java-based, platform-independent, software tool that can detect variants in next-generation sequencing (NGS) data. It employs a robust statistical approach to call variants and is able to handle germline variants, multi-sample variants, somatic mutations and somatic copy number alterati…
by | Mar 10, 2018 | Mirica, Liviu, Schultz, Jason, Sharma, Anuj
— Alzheimer’s disease (AD) is characterized by the deposition of amyloid plaques containing the amyloid beta (Aβ) peptide. Currently, no treatment is available for AD. Metal ion interactions of the Aβ peptide are believed to help formation of toxic aggregates. Developing chemical compo…
by | Mar 10, 2018 | Achilefu, Samuel, Biswas, Pratim, Raliya, Ramesh, Som, Avik
— Background: Physiological pH changes consistently affect millions of people worldwide. A slight variation in physiological pH exposes the body to various health risks, ranging from common heartburn to the formation of malignant tumors. Conventional methods for buffering pH are accomplished through a…
by | Mar 10, 2018 | Jeffe, Donna, Lieu, Judith, Umansky, Amy
— Approximately 5,000 infants are born with moderate, severe, or profound bilateral sensorineural hearing loss (HL) each year in the U.S. and many more have mild, unilateral, or progressive HL that will be identified in childhood. However, the degree of HL alone cannot predict a child’s language…
by | Mar 10, 2018 | Storch, Gregory
— Background: Viral infections are common causes of fever without an apparent source (FWS) in young children. Despite absence of bacterial infection, many febrile children are treated with antibiotics. Virus and bacteria interact with different pattern recognition receptors in circulating blood leuko…