by | Feb 20, 2020 | Ladenson, Jack, Landt, Yvonne, Laterza, Omar, Modur, Vijay
— Technology Description
Researchers in Prof. Jack Ladenson’s laboratory have discovered biomarkers and associated antibodies for Alzheimer’s disease (AD) that could be used for early/presymptomatic diagnosis or in clinical trials for AD drugs.
This patented technology is based on the i…
by | Feb 20, 2020 | Dougherty, Joseph, Hoye, Mariah, Hyman, Theodore, Koval, Erica, Miller, Timothy
— Prof. Timothy Miller and colleagues have identified a motor neuron-specific, drug responsive microRNA (miR-218) that reflects the pathology of amyotrophic lateral sclerosis (ALS). This biomarker could be a target for therapeutic intervention or a proxy for motor neuron health and survival, including…
by | Feb 20, 2020 | Ladenson, Jack, Young, Pampee
— Analyte: Small proline rich protein 3 (gene SPRR3)
Antibody codes: 3E9.1 (4587), 4G3.1 (4563), and 2F10.2 (4604)
Publications:
by | Feb 19, 2020 | Lew, Matthew, Mazidisharfabadi, Hesamaldin, Nehorai, Arye
— Engineers at Washington University have devised an automated system to enhance super-resolution microscopy images by detecting and quantifying image artifacts using no a priori information. This project stems from the advanced imaging research in Prof. Matthew Lew’s laboratory that includes op…
by | Feb 7, 2020 | Gale, Emily, Naegle, Kristen, Schaberg, Katherine, Sloutsky, Roman, Stoka, Kellie
— Background: Abnormal phosphorylation of proteins is associated with a number of human diseases including cancer, neurodegenerative disorders, and diabetes. Due to their role as phosphorlyators, kinases are popular drug targets. However, the difficulty of selectively phosphorylating a desired substra…