microRNA biomarker and drug target for ALS and other motor neuron diseases

by | Feb 20, 2020 | Dougherty, Joseph, Hoye, Mariah, Hyman, Theodore, Koval, Erica, Miller, Timothy

— Prof. Timothy Miller and colleagues have identified a motor neuron-specific, drug responsive microRNA (miR-218) that reflects the pathology of amyotrophic lateral sclerosis (ALS). This biomarker could be a target for therapeutic intervention or a proxy for motor neuron health and survival, including…