Search returned 736 results
C3-knockout miceWu, Xiaobo ; Atkinson, John
T-019398
— Genetic disruption of murine C3 promotor region generates deficient mice with extrahepatic expression of C3 mRNA
anti-IL-26 antibodiesColonna, Marco ; Cella, Marina
T-019424
— Mouse monoclonal antibodies recognizing human IL-26
BOOM-TCRtg miceDonermeyer, David ; Allen, Paul
T-019192
— BOOM TCRtg mice express a T cell receptor specific for the Bt4295(541-554) epitope of the commensal bacteria Bacteroids thetaiodaomicron. This is the first mouse TCRtg line developed specific for B. theta.
Two color HRas and single color CD86 plasmidsFoust, Daniel ; Piston, David
T-019195
— New combinations of labeled membrane proteins and G-protein subunits. These include twocolor HRas and single color CD86 controls as well as labels beta and gamma subunits of the heterotrimeric G-protein complex. All of these have been built using plasmids from Addgene.
PhOTseq and VNO ectopic expression plasmidsLee, Donghoon ; Holy, Timothy
T-019206
— These plasmids contain mammalian cell expression promoters and can be used for AAV production. Some plasmids encode a calcium reporter (GCaMP) and photoactivatable fluorescent reporter (PAmCherry). Others plasmids encode a calcium reporter (GCaMP) and one of the vomeronasal receptor genes; two gen…
Biomarker to predict cancer response to chemotherapyDiamond, Marc ; Shao, Jieya
T-015631
— Technology Description Researchers at Washington University in St. Louis have developed a prognostic biomarker that can be used to predict response to genotoxic chemotherapy for patients with basal-like/triple-negative breast cancer. Basal-like/triple-negative breast cancer is considered to be mor…
Device for diabetes cell replacement therapySong, Jiwon ; Millman, Jeffrey
T-016681
— Technology Description Researchers at Washington University in St. Louis have developed a 3D-printed device for the subcutaneous transplantation of stem cell-derived beta (SC-beta) cells for diabetes cell replacement therapy. Diabetes mellitus, a disease characterized by loss of blood glucose cont…
Eye test to diagnose preclinical Alzheimer’s diseaseVan Stavern, Gregory ; Apte, Rajendra
T-018518
— Technology Description Researchers at Washington University in St. Louis have developed a non-invasive screening method using optical coherence tomography angiography (OCTA) to detect Alzheimer’s disease (AD) at the early, preclinical stage. AD is characterized by progressive memory loss, be…
Device for diabetes cell replacement therapySong, Jiwon ; Millman, Jeffrey
T-016681
— Technology Description Researchers at Washington University in St. Louis have developed a 3D-printed device for the subcutaneous transplantation of stem cell-derived beta (SC-beta) cells for diabetes cell replacement therapy. Diabetes mellitus, a disease characterized by loss of blood glucose cont…
Prognostic for Lymphoproliferative DisordersQavi, Abraham ; Swat, Wojciech
T-019271
— Technology Description Researchers at Washington University in St. Louis have developed an improved method to monitor the progression of lymphoproliferative disorders (LPDs) and guide treatment decisions. LPDs, including leukemia and lymphoma, are characterized by the abnormal proliferation of blo…
Flexible, “Single-Shot” Image Reconstruction System for Faster EIXPCT (Edge Illumination X-ray Phase-Contrast Tomography)Guan, Huifeng ; Chen, Yujia ; Anastasio, Mark
T-016910
— Technology Description Joint reconstruction (“JR”) is a patented image reconstruction technique for “single shot” edge illumination x-ray phase-contrast tomography (EIXPCT). This system uses standard x-ray detection hardware and enables faster image acquisition times, lower…
Small molecules that inhibit Ebola viral VP35Amarasinghe, Gaya
T-019326
— VP35 is involved in multiple functions crticial to viral replication in filoviruses such as Ebola and Marburg virus. Viruses with VP35 mutations are attenuated in in vivo models. 5.4 million compounds were screened for their ability to bind to VP35 at the key protein-to-protein interface. The screen…
Mouse with Arg1809Cys Nf1 gene mutationGutmann, David
T-019336
— This mouse strain was designed to harbor a specific NF1 patient germline NF1 gene mutation.
Stem cells that produce decorinPferdehirt, Lara ; Guilak, Farshid
T-019343
— Using CRISPR-based gene editing, decorin was inserted downstream of Smad7 to create autoregulated stem cells that can produce decorin. As Smad7 is activated during TGF-beta signaling, the stems cells produce decorin in response to TGF-beta. Decorin is a key modulator of extracellular matrix assembly…
Vectors for study of Wolfram SyndromeAbreu, Damien ; Urano, Fumihiko
T-019395
— Dr. Fumihiko Urano is director of the Wolfram Syndrome International Registry at WU and has developed many research tools for studying Wolfram Syndrome. The following constructs contain the wildtype WFS1 gene with various flags, or mutations of WFS that cause mild forms of Wolfram Syndrome (019395)…
Humanized mouse model for Wolfram SyndromeUrano, Fumihiko
T-019402
— A mouse model of Wolfram Syndrome carrying a pathogenic variant of Wfs1 gene corresponding to human WFS1, c.1672C > T (p.R558c) missense mutation in exon 8 of WFS1.
Humanized rat model of Wolfram SyndromeUrano, Fumihiko
T-019403
— A humanized rat model of Wolfram Syndrome carrying a Wfs1 gene mutation corresponding to human WFS1 gene point mutation with a stop codon at position a.a. 452.
Elastin conditional knockout mouseWagenseil, Jessica ; Mecham, Robert
T-019289
— Mouse with floxed elastin gene to conditionally inactivate elastin gene expression. Publication: Heterogeneous Cellular Contributions to Elastic Laminae Formation in Arterial Wall Development
Mouse bladder cancer organoid cell line MCB6ABolzenius, Jennifer ; Arora, Vivek
T-019309
— MCB6A organoids generate urothelial tumors with features similar to the basal-squamous subtype of urothelial carcinoma, the most common bladder cancer. MCB6A harbors 1,524 mutations, including mutations in Kdm6a and Trp53. Publication: CD4+ T cells induce rejection of urothelial tumors after imm…
Plasmids for cyanobacterial CRISPRi and high sucrose productionPakrasi, Himadri
T-019345
— Plasmid for CRISPR interference in Synechococcus sp. UTEX 2973: pSL3287 (Addgene), included in publication: Tunable repression of key photosynthetic processes using Cas12a CRISPR interference in the fast-growing cyanobacterium Synechoccoccus sp. UTEX 2973 Plasmids for high level of sucrose produ…