— Technology Description Researchers at Washington University in St. Louis have developed a bead-based method to understand the functional states and metabolic capabilities of individual members of the human gut microbiota. The gut microbiota is increasingly linked to multiple aspects of human healt…

— Technology Description Researchers at Washington University in St. Louis and their colleagues have developed positron emission tomography (PET) tracers with high affinity for sigma-1 receptors. Sigma receptors have two subtypes, sigma-1 and sigma-2. Sigma-1 has high expression in the limbic and mo…

— Technology Description Researchers in Prof. Sandor Kovacs’ laboratory developed a patented, non-invasive, load-independent method to measure the intrinsic diastolic performance of the heart. This load-independent index of filling (LIIF) can be incorporated into the software of echocardiogram…

— Background: Cardiovascular disease, including acute myocardial injury (AMI), is responsible for over 610,000 deaths per year in the US making it the number one cause of death. The gold standard for AMI diagnosis relies on determination of the cardiac troponin I (cTnI) plasma level. The rise in the l…

— Technology Description: Researchers in Prof. Carlos Cruchaga’s laboratory have identified a sensitive and specific panel of circular RNAs (circRNA) that could be used for diagnosing, screening or monitoring patients with Alzheimer’s disease. The expression of these circRNAs tracks with …

— Technology Description Researchers at Washington University in St. Louis have developed a method to create designer stem cells which provide a safer, more effective cell therapy approach to treating disease. Cell-based regenerative therapies could potentially be used to treat many diseases and res…

— Technology Description Prof. Pratim Biswas and colleagues have developed an artificial intelligence platform to provide accurate, low-cost analysis of air and water quality by integrating data gathered from particulate matter (PM) sensors and other sources. This technology could be used to make th…

— Technology Description Engineers in Prof. Young-Shin Jun’s laboratory and Prof. Singamaneni’s laboratory have developed high performance, stable membrane materials that can be used for photothermal membrane distillation (PMD) to purify or desalinate water with minimal input of electric…

— Adeno-associated virus expressing WFS1, lentivirus expressing WFS1

— Eastern Equine Encephalitis virus (EEEV) antibodies

— Crispr developed SARM1 Knockout Rat

— Technology Description An interdisciplinary team at Washington University in St. Louis has developed patented adhesive-coated sutures with the potential to reduce ruptures following surgical repair of tendons and ligaments. These modified sutures are designed to minimize stress by shifting the mec…

— Mouse brain tumor cell line transduced with antigen

— APT1 deficient mouse

— Superficieibacter electus

— Human Monoclonal Antibodies: MD.03.1H06, MD.03.1B06, MD.03.1D11, MD.031F03, MD.03.1F11, MD.03.1H01, MD.025.2H09, MD.03.1G01, MD.025.2F10, MD.025.2B07, MD.025.2G11, MD.025.1F09, MD.025.1D01, MD.025.1H07, 306.012.7.1C10, 306.012.7.1A05, 10.036.7.1B04, 10.04.7.1B03

— Egr1Cre;Snap25Flp mice

— Cd40lg-Cre mouse

— VEEV E2 DNA plasmid

— Using the Cre-deletor strain Hoxb7-Cre, Washington University researchers developed transgenic mice with loxP sites flanking the gene for the glial cell line-derived neurotrophic factor (GDNF) family receptor α1 (GFRα1), which is involved in kidney tissue development. These mice were the…