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Tissue engineering scaffold for cell differentiation and delivery to intervertebral disc for treating lower back painSpeer, Julie ; Barcellona, Marcos ; Setton, Lori
T-019297
— Background: Severe low back pain and disability can result from intervertebral disc (IVD) degeneration caused by cell phenotype changes in the nucleus pulposus (NP) region. While autologous stem cells have be used to treat lower back pain, currently there are no tools to control differentiation of…
Tissue engineering scaffold for cell differentiation and delivery to intervertebral disc for treating lower back painSpeer, Julie ; Barcellona, Marcos ; Setton, Lori
T-019297
— Background: Severe low back pain and disability can result from intervertebral disc (IVD) degeneration caused by cell phenotype changes in the nucleus pulposus (NP) region. While autologous stem cells have be used to treat lower back pain, currently there are no tools to control differentiation of…
PI3K inhibitors to treat Cytokine Release SyndromeCarter, Alun ; DiPersio, John ; Amatya, Parmeshwar ; Cooper, Matthew
T-019429
— Technology Description A team of researchers, led by John DiPersio and Matthew Cooper at Washington University in St. Louis, have identified a small molecule kinase inhibitor capable of mitigating cytokine release syndrome following CAR-T cell therapy. PI3K inhibitors can suppress production of IL-…
Plasmids to express tagged genes in yeastRoy, Basab ; White, Michael A ; Granas, David ; Stormo, Gary
T-019559
— Three yeast plasmids that express yeast genes tagged with the fluorescent mCherry protein under the control of the GAL promoter. The genes were modified to be cre-less to so the plasmids could be used to study autoregulation in yeast. pMBJ1 pMBJ1-RPL1B-cl pMBJ1-RPS22-cl Publication: Roy, B., Gr…
Plasmid to test regulation 5′ untranslated sequences in yeastRoy, Basab ; White, Michael A ; Granas, David ; Stormo, Gary
T-019560
— This plasmid was created to test the regulatory impact of 5’ untranslated regions in yeast. It consists of EGFP under the control of the S. cerevisiae TEF2 promoter with cloning sites to modify the 5’UTR. Publication: Roy, B., Granas, D., Bragg, F., Cher, J. A., White, M. A., & Stor…
CD226 (DNAM1) knockout miceGilfillan, Susan ; Colonna, Marco
T-019563
— This is a mouse knockout strain for CD26, also known as DNAM-1 (DNAX accessory molecule 1). DNAM-1 is an adhesion molecule belonging to the immunoglobulin superfamily. This mouse model was used to study the role of DNAM-1 on CD8 T cell and NK cell function in vitro and in vivo. Publication: Gilfill…
CHIKV-3’Cre – recombinant Chikungunya virus expressing CreLenschow, Deborah
T-019567
— This is a recombinant clone of the Chikungunya LR2006 virus expressing Cre recombinase inserted downstream of a subgenomic promoter. In vitro transcription and transfection of RNA derived from this plasmid into cells will result in the generation of Chikungunya virus that expresses Cre recombinase i…
IL-34-deficient reporter mice (IL34 LacZ/LacZ)Colonna, Marco
T-019588
— Mouse strain deficient in IL-34 production with defective Langerhans cells and microglia. These mice can be used to assess the role of the cytokine IL-34 in the development and maintenance of peripheral macrophage populations. Publication: Wang, Y., Szretter, K. J., Vermi, W., Gilfillan, S., Rossin…
Ebola VP30 proteinsAmarasinghe, Gaya
T-019593
— Ebola viral protein 30 (eVP30) plays a critical role in transcription initiation for viral RNA synthesis. These materials could be used to test for Ebola virus infection. Publication: Xu, W., Luthra, P., Wu, C., Batra, J., Leung, D. W., Basler, C. F., & Amarasinghe, G. K. (2017). Ebola virus VP…
Broad spectrum chemokine receptor imaging agentLiu, Yongjian
T-019607
— 64Cu-DOTA-vMIP-II is a broad spectrum PET imaging agent that provides a non-invasive measurement of up to 10 chemokine receptors involved in the inflammatory processes of various diseases. This agent is based on the peptide vMIP-II (viral macrophage inflammatory protein-II), a viral CC chemokine enc…
ACE2 expressing cellsKumar, Sandeep ; Peterson, Timothy
T-019619
— These cells are K562 cells that express ACE2 (the receptor for SARS-CoV-2) from the endogenous locus and not a transgene.
CEPT1 floxed miceLodhi, Irfan ; Semenkovich, Clay
T-019637
— C57BL/6 ES cells were targeted with a vector (European Conditional Mouse Mutagenesis Program) carrying loxP sites flanking exon 3 of mouse Cept1. A karyotypically normal clone (of 10 correctly targeted) was injected into B6(Cg)-Tyrc-2J/J blastocysts and chimeric mice were bred with B6(Cg)-Tyrc2J/J f…
Generating pancreatic beta cells from pluripotent stem cells for diabetes cell therapy or drug developmentVeronese Paniagua, Daniel ; Wernes, Kristina ; Velazco-Cruz, Leonardo ; Hogrebe, Nathaniel ; Millman, Jeffrey
T-019409
— Technology Description: Researchers in Prof. Jeffrey Millman’s laboratory have developed multiple techniques for enhancing the differentiation, maturation and function of glucose-responsive, insulin-producing SC-beta cells (pancreatic beta cells made from human pluripotent stem cells). Downst…
An Intradermal Method for the Treatment of Hair Loss and AlopeciaYang, Pu ; Luo, Jialie ; Feng, Jing ; Hu, Hongzhen
T-017716
— Technology Description: A team of researchers, led by Hongzhen Hu, at Washington University in St. Louis has developed a method of treating hair loss and alopecia by intradermal injection targeting TRPV4 activation. Using a small molecule TRPV4 agonist, a single intradermal injection is sufficient…
“Gemini” connector device to prevent peripheral venous catheters from dislodging and leakingDerdeyn, Colin ; Genin, Guy ; Kim, Albert ; Norlin, James ; Scheid, Brittany ; Singamaneni, Srikanth ; Vemuri, Chandu ; Wang, Lihong ; Zipfel, Gregory ; Dacey, Ralph ; Bayly, Philip ; Arias, Eric ; Leuthardt, Eric
T-014841
— Technology Description A team of researchers at Washington University in St. Louis have developed the patented “Gemini” breakaway connector to turn peripheral venous catheter (PVC) fluid flow on and off without leaking. In addition, this easy-to-use device is designed to prevent PVC di…
Early, specific, blood-based diagnostic for septic arthritisLuhmann, Scott
T-018905
— Technology Description: Researchers at Washington University in St. Louis have identified blood-based cytokine signatures that could be used to specifically detect, distinguish and monitor septic arthritis, synovitis and osteomyelitis. This assay could enable timely, accurate treatment to avoid joi…
Interferon-gamma treatment to improve efficacy of hematopoietic stem cell transplantation for AML and other cancerPetti, Allegra ; Rettig, Michael ; Ley, Timothy ; DiPersio, John ; Christopher, Matthew
T-018954
— Technology Description Researchers at Washington University in St. Louis have discovered that interferon-gamma treatment could potentially prevent relapse after hematopoietic stem cell transplantation (HCT) treatment by making the cancer cells more visible to the donor immune cells. This technolog…
String Theory: Neurovascular Catheter System with 2-in-1 Variable RigidityLowe, Halle ; Osbun, Joshua ; Zayed, Mohamed ; Hartquist, Chase ; Hafez, Daniel ; Genin, Guy ; Chandrasekaran, Vinay ; Leuthardt, Eric
T-019184
— An interdisciplinary team at Washington University has developed an easy-to-use neurovascular catheter system designed to reduce surgery time and prevent herniation during transradial interventions for stroke, aneurysms and other conditions. This device, called “String Theory”, can be sw…
Barbed mesh for fast, suture-less surgical wound closureFelder, John
T-018828
— Technology Description: A surgeon at Washington University in St. Louis has designed a barbed mesh wound closure device with the potential to save time and improve outcomes by eliminating the need for surgical suturing to close incisions of the skin and fascia. This device has applications in a var…
String Theory: Neurovascular Catheter System with 2-in-1 Variable RigidityLowe, Halle ; Osbun, Joshua ; Zayed, Mohamed ; Hafez, Daniel ; Hartquist, Chase ; Genin, Guy ; Chandrasekaran, Vinay ; Leuthardt, Eric
T-019184
— An interdisciplinary team at Washington University has developed an easy-to-use neurovascular catheter system designed to reduce surgery time and prevent herniation during transradial interventions for stroke, aneurysms and other conditions. This device, called “String Theory”, can be sw…