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Conditional Lama5 Mutant Mice
Miner, Jeffrey
T-017526 Nanomaterials for Imaging and Treatment of Amyloidosis
Liu, Yongjian ; Guruswami, Sundaram ; Bieschke, Jan ; Sharma, Vijay
T-017876

— Background 8 million people per year are diagnosed with light-chain (AL) amyloidosis, a progressive disease than can quickly affect the kidney, heart, and nervous system if left untreated. The current method of diagnosis involves histological confirmation via biopsies of bone marrow, fat, and organ…

Design and Development of Organomedicinals for Imaging and Treatment of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia (FTD)
Sivapackiam, Jothilingam ; Guruswami, Sundaram ; Sharma, Vijay
T-016665

— Background Frontotemporal Dementia (FTD) is the second most common form of non-Alzheimer’s dementia in the population under 65 years old. FTD represents approximately 20% of all dementias and onset normally appears in the mid to late 50s. Clinically FTD is characterized by a progressive neur…

High Affinity Mannose Receptor Ligand
Stahl, Philip
T-000197

— Technology Description: The mannose receptor is uniquely found on macrophages and not on monocytes, making the mannose receptor a target for macrophage activation. Researchers at Washington University have developed polypeptide backbones to target the mannose receptor on macrophages. This technology…

Sensitive and Accurate Mass Spec-based assay for simultaneous quantification of glycosylsphingosine and galactosylsphingosine
Jiang, Xuntian ; Ory, Daniel
T-016077

— Background Gaucher and Krabbe disease are two types of lipid (fat) storage diseases that can result in progressive damage to the nervous system and other organ systems. Together, these diseases affect about 450,000 people worldwide. In both of these diseases, there is an undesirable accumulation of…

Triblock Copolymer Based Anion Exchange Membranes (Aems) As Separators in Electrochemical Devices
Ramani, Vijay ; Parrondo, Javier ; Wang, Zhongyang
T-017637

— Background: Anion exchange membranes (AEMs) are used as separators in redox flow batteries, water electrolyzers, water desalination systems, fuel cells, and other electrochemical devices. Current AEMs suffer from issues with cost, poor stability and low perm selectivity. For example, current redox flow batteries are not economical or suffer from capacity loss upon cycling due to cross species contamination while using less expensive decoupled chemistries.An advanced, tunable AEM has been developed with dramatically reduced cost and improved performance relative to industry leading AEMs. High ionic conductivity, chemical stability and enhanced mechanical performance have been shown. The technology includes tunable membrane compositions, mechanical re…

pTAT/pTAT-HA plasmids and protein purfication protocol (Vectors are on deposit with Addgene)
Dowdy, Steven
T-000717

— Technology Description: Researchers at Washington University have developed a method that allows the transduction of full-length proteins by utilizing the pTAT or pTAT-HA protein expression plasmids. A protein of choice can be fused to a HIV-TAT transduction domain under the expression system. Ba…

Microbiome Biomakers of Obesity
Turnbaugh, Peter ; Gordon, Jeffrey
T-007697

— Technology Summary: Obesity rates worldwide are increasing at an astounding rate. While diet, lifestyle, and physical activity have traditionally been identified as the main causative factors, researchers at Washington University are the first to implicate gut bacteria (microbiome) as a new drivin…

SILTmass software
Bateman, Randall ; Elbert, Donald
T-008416

— Background Quantitation of relative or absolute amounts of proteins by mass spectrometry can be prone to large errors. The use of MS/MS ion intensities and stable isotope labeling, a method called isotope labeling tandem mass spectrometry (SILT), decreases the effects of contamination from unrelate…

Universal Targeted Drug Delivery and Imaging Platform
Li, Ruihan ; Li, Xuesong ; Delawder, Abigail "Abby" ; Barnes, Jonathan
T-018548

— Background Targeted delivery of cytotoxic therapeutics is crucial to prevent adverse side effects of chemotherapy and to increase drug concentrations at the tumor site. These prerequisites also apply to the treatment of infections caused by multiple drug resistant bacteria. To address this unmet n…

Reproducible High Yielding Cu-64 Radioisotope Manufacturing
Zerkel, Patrick ; Lawrence, Luke ; Gaehle, Gregory
T-018514

— Background: Its unique imaging characteristics and favorable half-life and decay properties make radioisotope copper-64 (Cu-64) most desirable for PET imaging. To meet the increasing demand, an efficient high yielding Cu-64 manufacturing process is essential. To address this unmet need, scientists f…

CellTags: Tracking Individual Cells during Cell Reprogramming
Morris, Samantha
T-018555

— Background Cell populations are quite heterogeneous yet are typically analyzed in bulk, masking unique behavioral features. This is particularly problematic in cell reprogramming, where in a given population of cells, only a small number complete reprogramming. Single-cell technologies address the …

Non-invasive Technology Enables Brain Tumor Biopsy Without Surgery
Petti, Allegra ; Dunn, Gavin ; Chen, Hong ; Leuthardt, Eric
T-017113

— Background: The American Brain Tumor Association reports that about 80,000 of the estimated 700,000 Americans that live with a brain tumor have been diagnosed in 2017. The surgery required for a traditional brain tumor biopsy entails making a hole in the skin and skull, placing a needle probe, and r…

Targeting CD5+ Dendritic Cell in Skin for the Treatment of Chronic Diseases
Klechevsky, Eynav
T-016609

— Background Dendritic cells (DCs) are antigen-presenting cells that are essential to the adaptability of the immune system. Several subsets of DCs have been identified in tissues that interface with the environment (e.g. skin, mucosal lining). While the role of specific DC subsets are unknown, DCs p…

Tools for the Detection of High-Density Lipoprotein Transport To and From Tissues
Zinselmeyer, Bernd ; Huang, Li-Hao ; Randolph, Gwendalyn
T-015939

— Background High-density lipoproteins (HDLs) have been widely studied and linked to various diseases, especially metabolic diseases. HDL levels in the blood have traditionally been used as a benchmark for risk of cardiovascular disease. However, these blood tests may be misleading – HDL levels…

MicroRNA-induced Direct Conversion of Human Adult Fibroblasts into Neurons
Abernathy, Daniel ; Yoo, Andrew
T-017136

— Background: Studying late-onset neurodegenerative disorders using patient-specific neurons is one of the primary goals of precision medicine. The ability to generate human neurons that mimic the neurons of elderly individuals will provide an instrumental platform to model and study adult-onset neuro…

Comfortable radiotherapy couch to improve precision and accuracy
Mutic, Sasa ; Zhao, Tianyu
T-018538

— Background: High precision and accuracy is critically needed for the use of radiation treatment and diagnostic imaging (magnetic resonance imaging, computerized tomography, X-ray, positron emission tomography); each of these modalities uses the standard flat couch to manipulate the patient during pr…

Targeting hepatic arginine metabolism for treatment of metabolic diseases
Zhang, Yiming ; Mayer, Allyson ; Higgins, Cassandra ; DeBosch, Brian
T-017417

— Background Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease. Technology Summary Pharmacological or genetic activation of the Arginine…

Cochlear Fluids Simulator
Salt, Alec
T-018692

— Background: Local drug therapy of the inner ear became popular in the 1990s to treat a number of ear disorders. Local therapy allows the drug to bypass entry barriers, reducing systemic toxicities. For novel drugs to be delivered to the inner ear, pharmacokinetic (PK) values such as half-life and ma…

Spinning Spheres for Magnetic Resonance
Albert, Brice ; Barnes, Alexander
T-017912

— Background: A commonly used approach for the analysis of the molecular structure, content, and purity of solid and liquid samples is magic angle spinning nuclear magnetic resonance (MAS NMR). This technique provides greater resolution to better identify and analyze chemical spectra compared to solid…