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human iPSC cells to model VCPWeihl, Conrad
T-019162
— Valosin Containing Protein (VCP) patient derived fibroblasts, reprogrammed into iPSC cells and corresponding gene corrected line. These cells can be used to model VCP associated muscle disease, ALS, and dementia.
B-122 and Alf-161 – Hamster IgG Monoclonal Antibodies against Mouse/Rat IL-1 Beta and Mouse IL-1 AlphaSchreiber, Robert
T-000125
— Target: Mouse/rat interleukin-1 beta and mouse interleukin-1 alpha. Located on macrophages, dendritic cells, T and B cells. Notes: Clone name is B-122 and Alf-161Information on antibodies against IL-1 beta: The role of murine IL-1 beta in vitro and in vivo has not been defined. We describe here the production of neutralizing and immunoprecipitating mAb and polyclonal antibodies specific for murine IL-1 beta and their application to a characterization of the…
Armenian hamster anti-mouse TCR Vb 8.3 IgG3 monoclonal antibody (clone 1B3.3)Allen, Paul
T-000304
— Target: Full length mouse Vb 8.3 TCR but not 8.1 or 8.2. Vb 8.3. Application: Flow cytometryThis antibody was made by immunizing Armenian hamsters. It was used to study the mechanisms that act to keep only one functional TCR beta-chain per cell and the effect of selecting ligand density on positive selection and endogenous receptor usage in mice. Publication: TCR transgenic mice in which …
Hamster Hybridoma producing Monoclonal Antibody against Murine CD272 (BTLA)Sedy, John ; Murphy, Theresa ; Hurchla, Michelle ; Murphy, Kenneth
T-004458
— Target: B and T lymphocyte attenuator (BTLA). BTLA is expressed on peripheral lymphocytes, splenic macrophages and select developing B and T cells.Inventors created the monoclonal antibodies by immunizing Armenian hamster or BALB/c background BTLA -/- mice. Hamster monoclonal 6A6 is of the IgG isotype, whereas all murine Abs are IgG1κ. Some of the antibodies recognize the mouse BTLA C57/BL6 allele (6A6, 3F9.C6) and some are panspecific (…
Murine Hybridoma producing IgG1 Monoclonal Antibody to Human CD96 (Tactile)Colonna, Marco
T-005374
— Target: CD96 is a T cell-specific receptor indicative of T cell activation. Notes: Clone name NK92.39.1. For use in flow cytometry.Researchers generated the antibodies by immunizing mice with NK92 cells and selected hybridomas that plocked binding of PVR to NK92. These antibodies have been used to study natural killer cell target cell adhesion. Publication: Cutting Edge: CD96 (Tactile) Promotes NK Cell-Target Cell Adhesion by …
Achondroplasia (ACH) Mouse ModelOrnitz, David
T-000483
— Target: Mouse model with the mutation for ACH knocked in.Description: Inventors created a transgenic mouse model of achondroplasia by targeting the expression of activated FGFR3 to growth plate cartilage in mice using regulatory elements from the collagen II gene. As with humans carrying the achondroplasia mutation, the resulting transgenic mice were dwa…
Crry-deficient mouse strainAtkinson, John ; Molina-Vicenty, Hector
T-003105
— Crry-knockout mouse strain (Crry -/-)Researchers generated mice deficient in Crry by disrupting exon 5 of the mouse Crry gene. The mice are sensitive to complement deposition and activation, especially the C3 component of complement on the surface of the placenta. Publication: A Critical Role for Murine Complement Regulator Crry in Fe…
Piggybac vectors for gene delivery and fluorescent reporter assaysMadison, Blair
T-019191
— Plasmid vectors for shRNA expression, CRISPR reagent delivery, protein expression, reporter (promoter or 3’UTR) assays, and non-coding RNA delivery Efficient gene delivery is problematic, especially in hard to transfect primary cells (e.g. organoids). Commercial piggybac vectors are sparse and …
Ifnl2/Ifnl3 double knock-out mouseBaldridge, Megan
T-019187
— Ifnl2/Ifnl3 double knock-out mouse strain This mouse strain is in the C57BL/6 background with Ifnl2, Ifnl3 genes disrupted to create a double knock-out. It was generated with assistance from the Washington University GEIC. This strain was used to study the regulation of the innate immune response t…
Low cost electrode decoupled redox flow batteries for grid-scale energy storageRamani, Vijay ; Sankarasubramanian, Shrihari
T-018530
— Technology Description Engineers in Prof. Vijay Ramani’s laboratory have developed an electrode decoupled redox flow battery (RFB) with stable electrolyte materials that can generate power densities comparable to all-Vanadium RFBs at less than half the cost. RFBs are a promising option for …
Murine Hybridoma producing Monoclonal Antibodies against Human NKp44Colonna, Marco
T-004356
— Target: NKp44 is a novel triggering surface molecular specifcially expressed by activated natural killer cells. Notes: Clone name 448.189 Marco Colonna, MDInventors generated NKp44 monocolonal antibodies by immunizing mice with a NKp44-human crystallizable fragment (Fc) fusion protein. The antibodies have been used to study innate and adaptive immune responses. Publication: Paradoxic inhibition of human natural interferon-producing cells by the activ…
STAT1 Knockout MiceSchreiber, Robert
T-001007
— Notes: STAT1-/- knockout mouse with a 129S6 backgroundInventors used homologous recombination techniques to create mice that lack functionally active STAT1. Characterization studies reveal that STAT1-deficient mice display a global state of unresponsiveness to either IFNα or IFNγ and are unable to resolve infections by microbial pathogens a…
IL-1 beta deficient miceFerguson, Thomas ; Chaplin, David
T-001876
— Mouse strain deficient in IL-1 betaInventors created the IL-1 beta deficient mouse strain by targeting the IL-1 beta gene in embryonic stem cells. These mice develop and grow normally. Endotoxin-stimulated peritoneal macrophages from IL-1beta- deficient mice showed normal synthesis and cellular release of IL- 1alpha after treatment w…
High-speed, low-cost, short-haul optical communications with on-chip polarization division multiplexingIvanovich, Darko ; Gruev, Viktor ; Chamberlain, Roger
T-018955
— Technology Description Engineers in Prof. Roger Chamberlain’s laboratory have developed a low-cost multiplexing technology for high-speed optical communications in data centers and other short-haul applications. This visible light communication (VLC) system is designed to create distinct par…
Steerable Thermoablation Probe for Improved Access to Brain LesionsLeuthardt, Eric
T-015768
— Technology Description An interdisciplinary team led by Professor Eric Leuthardt has developed a steerable device that can be integrated into existing thermoablation systems to treat abnormal brain lesions. Thermoablation is a more targeted and less disruptive method for treating lesions than chem…
Targeting hepatic arginine metabolism for treatment of metabolic diseasesZhang, Yiming ; Mayer, Allyson ; Higgins, Cassandra ; DeBosch, Brian
T-017417
— Background Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease. Technology Summary Pharmacological or genetic activation of the Arginine…
Comfortable radiotherapy couch to improve precision and accuracyMutic, Sasa ; Zhao, Tianyu
T-018538
— Background: High precision and accuracy is critically needed for the use of radiation treatment and diagnostic imaging (magnetic resonance imaging, computerized tomography, X-ray, positron emission tomography); each of these modalities uses the standard flat couch to manipulate the patient during pr…
Therapeutic food supplements that promote healthy gut microbiome to treat malnutritionVenkatesh, Siddarth ; Gehrig, Jeanette ; Chang, Hao-Wei ; Barratt, Michael ; Gordon, Jeffrey
T-018889
— Technology Description Prof. Jeffrey Gordon and his colleagues have developed an inexpensive food formulation that could treat malnutrition and a range of associated health problems by repairing the gut microbiome. Children who are malnourished are currently treated with supplemental nutrition tha…
Rotoscope – A Self-Cleaning EndoscopeYarbrough, Chester ; Somers, Thane ; Margolis, Daniel ; Genin, Guy ; Leuthardt, Eric
T-016245
— Technology Description: Drs. Eric Leuthardt and Guy Genin have devised a medical device designed for faster and safer endoscopic surgeries. During these surgeries, the camera lens of the endoscope can become obscured with blood, fog and debris. This slows down the procedure, as the surgeon has to r…
Simple, stable plasmonic biosensors for point-of-care diagnosis of cardiac arrest and other conditionsTadepalli, Sirimuvva ; Morrissey, Jeremiah ; Kharasch, Evan ; Singamaneni, Srikanth
T-014923
— Technology Description An interdisciplinary team of researchers at Washington University have developed a sensitive, shelf-stable, label-free system for quickly quantifying biomarkers in point-of-care settings (e.g., office, ambulance or battlefield). Localized surface plasmon resonance (LSPR) off…